CAS 199119-46-5

N-im-Trityl-D-histidine

Description:

N-im-Trityl-D-histidine is a modified amino acid derivative of histidine, characterized by the presence of a trityl group, which enhances its stability and solubility. This compound is notable for its role in peptide synthesis and as a building block in the development of pharmaceuticals and bioconjugates. The trityl group, a bulky protecting group, is typically used to shield the amino group during chemical reactions, allowing for selective modifications of other functional groups. N-im-Trityl-D-histidine retains the essential properties of histidine, including its ability to participate in acid-base reactions due to the imidazole side chain, which can act as both a proton donor and acceptor. This characteristic makes it valuable in various biochemical applications, including enzyme catalysis and protein engineering. Additionally, the D-configuration of this amino acid can influence the stereochemistry of peptides, potentially affecting their biological activity. Overall, N-im-Trityl-D-histidine is a versatile compound in synthetic organic chemistry and biochemistry.

Synonyms:

• H-D-His(tau-Trt)-OH
• H-D-His(Trt)-OH
• 1-(Triphenylmethyl)-D-histidine
• Arg(Pbf)

D-Histidine, 1-(triphenylmethyl)-

CAS: 199119-46-5

Formula: C₂₅H₂₃N₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 397.4690

Ref: IN-DA002BX9

H-D-His(Trt)-OH

CAS: 199119-46-5

H-D-His(Trt)-OH

Purity: 98%

Ref: 54-OR1037660

D-Histidine, 1-(triphenylmethyl)-

CAS: 199119-46-5

Purity: 98%

Molecular weight: 397.48

Ref: 10-F865815

Nim-Trityl-D-histidine

Controlled Product

CAS: 199119-46-5

Applications Nim-Trityl-D-histidine is used as a reagent in solid-phase synthesis and screening of peptides as catalysts for asymmetric induction of desymmetrization of bis(phenol)s.
References Lewis, C. A., et al.: J. Am. Chem. Soc., 130, 16358 (2008); Keith, J., et al.: Adv. Synth. Catal, 5, 343 (2001)

Formula: C₂₅H₂₃N₃O₂

Color and Shape: Neat

Molecular weight: 397.47

Ref: TR-N476200