CAS 19943-27-2
:Cyclo(L-prolyl-L-prolyl)
Description:
Cyclo(L-prolyl-L-prolyl), also known as cyclo(Pro-Pro), is a cyclic dipeptide composed of two proline amino acids linked in a head-to-tail arrangement. This compound is characterized by its unique cyclic structure, which influences its conformational properties and biological activity. The presence of the proline residues contributes to its rigidity and the ability to adopt specific three-dimensional shapes, which can be crucial for interactions with biological targets. Cyclo(L-prolyl-L-prolyl) is known for its potential roles in various biological processes, including acting as a signaling molecule or influencing protein folding. Its stability and resistance to enzymatic degradation make it of interest in pharmaceutical and biochemical research. Additionally, the compound's properties, such as solubility and reactivity, can vary depending on the surrounding environment, including pH and solvent conditions. Overall, cyclo(L-prolyl-L-prolyl) serves as an important model for studying cyclic peptides and their applications in drug design and development.
Formula:C10H14N2O2
InChI:InChI=1S/C10H14N2O2/c13-9-7-3-1-5-11(7)10(14)8-4-2-6-12(8)9/h7-8H,1-6H2/t7-,8-/m0/s1
InChI key:InChIKey=BKASXWPLSXFART-YUMQZZPRSA-N
SMILES:O=C1[C@]2(N(C(=O)[C@]3(N1CCC3)[H])CCC2)[H]
Synonyms:- Cyclo-L-prolyl-L-proline
- 5H,10H-Dipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione, octahydro-, (5aS,10aS)-
- (5aS,10aS)-Octahydro-5H,10H-dipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione
- Cyclo(L-prolyl-L-prolyl)
- 5H,10H-Dipyrrolo[1,2-a:1′,2′-d]pyrazine-5,10-dione, octahydro-, (5aS-cis)-
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Found 3 products.
Cyclo(L-Pro-L-Pro)
CAS:<p>Cyclo(L-Pro-L-Pro) is a cyclic peptide that was first synthesized in 1968 by the chemists, K. Brown and H. M. Schuster. Cyclo(L-Pro-L-Pro) has been shown to produce p-hydroxybenzoic acid, an intermediate in the metabolism of dopamine, when incubated with human serum or human erythrocytes. In addition, it has been shown to increase locomotor activity and enzyme activities in rats, as well as cytosolic calcium levels in cells. This compound may be a useful experimental model for studying Parkinson's disease because of its ability to inhibit dopamine uptake and increase the production of dopamine from its precursor L-DOPA. It also binds to neurokinin 1 receptor (NK1R), which is involved in inflammatory responses and pain sensation.</p>Formula:C10H14N2O2Purity:Min. 95%Molecular weight:194.23 g/mol
