CAS 199593-09-4

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Description:

N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite is a modified nucleoside phosphoramidite used primarily in the synthesis of oligonucleotides. This compound features several key characteristics: it contains a nucleobase (cytidine) modified at the 2' position with a methyl group, enhancing its stability and resistance to enzymatic degradation. The presence of the 5'-O-(4,4-dimethoxytrityl) group serves as a protective moiety, facilitating the synthesis of oligonucleotides by preventing premature reactions. The cyanoethyl group attached to the phosphoramidite moiety is crucial for the coupling reaction during oligonucleotide synthesis, allowing for the formation of phosphodiester bonds. Additionally, the N-acetyl group contributes to the overall solubility and stability of the compound. This phosphoramidite is typically utilized in automated synthesizers for the production of RNA or DNA sequences, making it valuable in research and therapeutic applications, including gene therapy and antisense oligonucleotide development.

Formula: C₄₂H₅₂N₅O₉P

Synonyms:

• 2'-O-Methyl-rC(N-Ac)Phosphoramidite
• 5'-O-DMT-2'-O-Me-rC(N-Ac)-3'-CEDPA
• 2'-OMe-Ac-C Phosphoramidite
• 2'-O-Methyl-N4-Acetyl-5'-O-DMT-Cytidine-3'-CE-Phosphoramidite
• DMT-2-O-ME-C-CE Phosphoramidite

DMT-2'-O-methyl-rC(Ac) Phosphoramidite

CAS: 199593-09-4

Formula: C₄₂H₅₂N₅O₉P

Purity: >95.0%(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 801.88

Ref: 3B-D5703

Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

CAS: 199593-09-4

Formula: C₄₂H₅₂N₅O₉P

Purity: 97%

Color and Shape: Solid

Molecular weight: 801.8641

Ref: IN-DA002C7V

N4-Acetyl-5''-O-DMT-2''-O-methylcytidine 3''-CE phosphoramidite

CAS: 199593-09-4

Ref: 7W-GN1530

2'-OMe-Ac-C Phosphoramidite

CAS: 199593-09-4

2'-OMe-Ac-C Phosphoramidite, a modified phosphoramidite, is utilized in the synthesis of oligonucleotides.

Formula: C₄₂H₅₂N₅O₉P

Color and Shape: Solid

Molecular weight: 801.86

Ref: TM-T75265

2'-Ome-Ac-C Phosphoramidite

CAS: 199593-09-4

2'-Ome-Ac-C Phosphoramidite

Purity: 98%

Molecular weight: 801.86g/mol

Ref: 54-OR1029559

N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite

CAS: 199593-09-4

N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite is a novel nucleoside, which is modified with a acetyl group and an O-methylation at the 2' position. It has been shown to inhibit tumor growth in vivo by inducing apoptosis and cell cycle arrest. N4-Acetyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite also has antiviral activity against HIV and can be used to activate transcription from RNA polymerase II promoters. This product is intended for research purposes only.

Formula: C₄₂H₅₂N₅O₉P

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 801.88 g/mol

Ref: 3D-PA08595

2′-OMe-Ac-C Phosphoramidite

CAS: 199593-09-4

Purity: 97%

Molecular weight: 801.878

Ref: 10-F986770

2'-OMe-Ac-C Phosphoramidite (~90%)

Controlled Product

CAS: 199593-09-4

Applications 2'-OMe-Ac-C Phosphoramidite (CAS# 199593-09-4) is a nucleotide used in the solid-phase synthesis of phosphorothioate oligonucleotides using sulfurization byproducts for in situ capping.
References Yang, J.; et al.: J. Org. Chem., 83, 11577 (2018);

Formula: C₄₂H₅₂N₅O₉P

Purity: ~90%

Color and Shape: Neat

Molecular weight: 801.88

Ref: TR-K592005