CAS 199666-03-0

3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide

Description:

3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide is a synthetic organic compound characterized by its complex structure, which includes a sulfonamide group, methoxy substituents, and a thiazole ring. The presence of the thiazole moiety contributes to its potential biological activity, as thiazoles are often found in pharmacologically active compounds. The nitrophenyl group enhances the compound's electronic properties, potentially influencing its reactivity and interaction with biological targets. This compound is typically used in research settings, particularly in medicinal chemistry, where it may serve as a lead compound for the development of new therapeutic agents. Its solubility, stability, and reactivity can vary based on environmental conditions and the presence of other chemical species. Safety and handling precautions are essential due to the presence of the nitro group, which can pose risks associated with toxicity and environmental impact. Overall, this compound exemplifies the intricate design often employed in the development of novel pharmaceuticals.

Formula: C₁₇H₁₅N₃O₆S₂

InChI: InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19)

InChI key: InChIKey=NDPBMCKQJOZAQX-UHFFFAOYSA-N

SMILES: N(S(=O)(=O)C1=CC(OC)=C(OC)C=C1)C2=NC(=CS2)C3=CC(N(=O)=O)=CC=C3

Synonyms:

• 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
• Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-
• Ro 61-8048
• 3,4-Dimethoxy-N-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]benzenesulfonamide

Benzenesulfonamide, 3,4-dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]-

CAS: 199666-03-0

Formula: C₁₇H₁₅N₃O₆S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 421.4475

Ref: IN-DA002C9V

Ro 61-8048

CAS: 199666-03-0

Ro 61-8048

Purity: ≥98%

Molecular weight: 421.45g/mol

Ref: 54-BUP12949

3,4-Dimethoxy-N-(4-(3-Nitrophenyl)Thiazol-2-yl)Benzenesulfonamide

CAS: 199666-03-0

3,4-Dimethoxy-N-(4-(3-Nitrophenyl)Thiazol-2-yl)Benzenesulfonamide

Purity: 98%

Molecular weight: 421.45g/mol

Ref: 54-OR1026251

Ro 61-8048

CAS: 199666-03-0

Formula: C₁₇H₁₅N₃O₆S₂

Molecular weight: 421.45

Ref: 7W-GK6422

Ro 61-8048

CAS: 199666-03-0

Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM.

Formula: C₁₇H₁₅N₃O₆S₂

Purity: 98% - >99.99%

Color and Shape: Solid

Molecular weight: 421.45

Ref: TM-T1896

Ro 61-8048

CAS: 199666-03-0

Ro 61-8048 is a small-molecule drug that inhibits the nicotinic acetylcholine receptor (nAChR) of the α7 type. It has been shown to be effective in vivo, inhibiting neuronal death and preventing virus replication. Ro 61-8048 also prevents picolinic acid-induced glutamate release and microdialysis probes, which may be due to its effect on the phase transition temperature of polymerase chain reactions. Ro 61-8048 has shown efficacy in vitro and can be used to treat neurodegenerative diseases such as HIV dementia, Alzheimer's disease, and Parkinson's disease. The effects of Ro 61-8048 have been tested against untreated groups and those treated with pharmacological treatment. The drug was found to inhibit binding to α7 nAChRs in vitro by binding at the same site as nicotine or other agonists.

Formula: C₁₇H₁₅N₃O₆S₂

Purity: Min. 95%

Molecular weight: 421.45 g/mol

Ref: 3D-BR170575