CAS 199739-10-1

Paliperidone Palmitate

Description:

Paliperidone palmitate is an atypical antipsychotic medication primarily used in the treatment of schizophrenia and schizoaffective disorder. It is an extended-release formulation of paliperidone, which is the active metabolite of risperidone. This compound is characterized by its long-acting properties, allowing for less frequent dosing compared to oral antipsychotics. Chemically, paliperidone palmitate is a palmitate ester of paliperidone, which enhances its lipophilicity and facilitates sustained release into the bloodstream. The substance is typically administered via intramuscular injection, providing therapeutic effects over an extended period, often up to a month. Its mechanism of action involves antagonism of dopamine D2 and serotonin 5-HT2A receptors, contributing to its efficacy in managing psychotic symptoms. Common side effects may include weight gain, sedation, and metabolic changes. As with other antipsychotics, careful monitoring is essential to manage potential adverse effects and ensure patient safety. Overall, paliperidone palmitate represents a significant advancement in the pharmacological management of chronic psychiatric conditions.

Formula: C₃₉H₅₇FN₄O₄

InChI: InChI=1S/C39H57FN4O4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-18-36(45)47-34-17-16-24-44-38(34)41-29(2)32(39(44)46)23-27-43-25-21-30(22-26-43)37-33-20-19-31(40)28-35(33)48-42-37/h19-20,28,30,34H,3-18,21-27H2,1-2H3

InChI key: InChIKey=VOMKSBFLAZZBOW-UHFFFAOYSA-N

SMILES: FC=1C=C2C(C(=NO2)C3CCN(CCC=4C(=O)N5C(=NC4C)C(OC(CCCCCCCCCCCCCCC)=O)CCC5)CC3)=CC1

Synonyms:

• (9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyrimidin-9-yl hexadecanoate
• 9-Hydroxyrisperidone palmitate
• Hexadecanoic acid, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido(1,2-a)pyrimidin-9-yl ester
• Invega Sustenna
• Paliperidone Palmitate [USAN]
• Ro 92670
• Ro92670
• Trevicta
• Unii-R8P8Usm8Fr
• Xeplion
• Paliperidone palmitate
• Paliperidone palmitate
• (9RS)-3-(2-(4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl)et
• Paliperidone Palmitate Benzisoxazole Impurity
• hyl)-2-Methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido(1,2-a)pyriMi
• Hexadecanoic acid 3-[2-[4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl]-ethyl]-6,7,8,9-tetrahydro-2-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl ester
• Paliperidone Palmitate USP/EP/BP
• Paliperidone Palmitate-d31
• 3-(2-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)ethyl)-2-methyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-9-yl palmitate
• Paliperidone palmitateQ: What is
• Paliperidone palmitate Q: What is the CAS Number of
• Paliperidone palmitate Q: What are the applications of
• din-9-yl hexadecanoate
• Paliperidone Impurity 39 (Paliperidone Palmitate)

Paliperidone Palmitate

CAS: 199739-10-1

Formula: C₃₉H₅₇FN₄O₄

Color and Shape: Off-White Solid

Molecular weight: 664.91

Ref: 4Z-P-664

Paliperidone Palmitate

CAS: 199739-10-1

Color and Shape: Neat

Ref: 86-MM3627.00

Paliperidone Palmitate

CAS: 199739-10-1

Paliperidone: atypical antipsychotic, dopamine & serotonin antagonist, affects α1/α2 adrenergic and H1 histamine receptors.

Formula: C₃₉H₅₇FN₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 664.89

Ref: TM-T19950

Paliperidone Palmitate-d31

CAS: 199739-10-1

Formula: C₃₉H₂₆FN₄O₄D₃₁

Molecular weight: 696.10

Ref: 4Z-P-6626

Paliperidone palmitate

Controlled Product

CAS: 199739-10-1

Paliperidone palmitate is a drug that is used in the treatment of schizophrenia. It is the most potent and selective atypical antipsychotic agent available. Paliperidone palmitate has shown long-term efficacy and low risk of extrapyramidal symptoms, which are associated with some other antipsychotic agents. The drug has been shown to have minimal effects on prolactin levels, although it can cause an increase in serum prolactin levels when administered with risperidone. Paliperidone palmitate is a prodrug that is metabolized by esterases to its active form, paliperidone. Paliperidone does not bind to plasma proteins and therefore may be more suitable for patients with hepatic impairment.

Formula: C₃₉H₅₇FN₄O₄

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 664.89 g/mol

Ref: 3D-FP26726

Paliperidone Palmitate

CAS: 199739-10-1

Applications Paliperidone Palmitate is a long-acting injectable atypical antipsychotic used in the treatment of schizophrenia.
References Hough, D. et al.: Prog. Neuro-psychophamacol. Biol. Psych., 33, 1022 (2009); Samtani, M.N. et al.: Clin. Pharmacokin., 48, 585 (2009); Nasrallah, H.A. et al.: Neuropsychopharmacology, 35, 2072 (2010);

Formula: C₃₉H₅₇FN₄O₄

Color and Shape: Neat

Molecular weight: 664.89

Ref: TR-P141020

Paliperidone Palmitate

CAS: 199739-10-1

Formula: C₃₉H₅₇FN₄O₄

Molecular weight: 664.91

Ref: ST-EA-CP-P13055