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CAS 199796-52-6

:

DHA-paclitaxel

Description:
DHA-paclitaxel, with the CAS number 199796-52-6, is a novel chemotherapeutic agent that combines paclitaxel, a well-known anticancer drug, with docosahexaenoic acid (DHA), an omega-3 fatty acid. This conjugation aims to enhance the solubility and bioavailability of paclitaxel while potentially reducing its side effects. DHA-paclitaxel exhibits characteristics typical of both components: it retains the ability to inhibit cancer cell proliferation by stabilizing microtubules, a mechanism of action shared with paclitaxel, while also benefiting from the anti-inflammatory properties of DHA. The compound is often studied for its efficacy against various cancer types, including breast and ovarian cancers. Its formulation may improve drug delivery to tumor sites, leveraging the natural properties of DHA to facilitate cellular uptake. Additionally, DHA-paclitaxel is of interest in research for its potential to enhance therapeutic outcomes and minimize toxicity compared to conventional paclitaxel treatments. Overall, DHA-paclitaxel represents a promising approach in cancer therapy, combining the strengths of both paclitaxel and DHA.
Formula:C69H81NO15
InChI:InChI=1S/C69H81NO15/c1-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-35-42-55(74)83-59(57(49-36-29-26-30-37-49)70-63(76)50-38-31-27-32-39-50)65(78)82-52-44-69(79)62(84-64(77)51-40-33-28-34-41-51)60-67(7,53(73)43-54-68(60,45-80-54)85-48(4)72)61(75)58(81-47(3)71)56(46(52)2)66(69,5)6/h9-10,12-13,15-16,18-19,21-22,24-34,36-41,52-54,57-60,62,73,79H,8,11,14,17,20,23,35,42-45H2,1-7H3,(H,70,76)/b10-9-,13-12-,16-15-,19-18-,22-21-,25-24-/t52-,53-,54+,57-,58+,59+,60-,62-,67+,68-,69+/m0/s1
InChI key:InChIKey=LRCZQSDQZJBHAF-PUBGEWHCSA-N
SMILES:O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](OC(C)=O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)OC(CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CC)=O)=O)C5)[H]
Synonyms:
  • Benzenepropanoic acid, β-(benzoylamino)-α-[[(4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaen-1-yl]oxy]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
  • Paclitaxel 2′-(all-cis-4,7,10,13,16,19-docosahexaenoate)
  • Benzenepropanoic acid, β-(benzoylamino)-α-[[(4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaenyl]oxy]-, mono[(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl] ester, (αR,βS)-
  • Benzenepropanoic acid, β-(benzoylamino)-α-[(1-oxo-4,7,10,13,16,19-docosahexaenyl)oxy]-, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-
  • Taxoprexin
  • Paclitaxel Impurity 98
  • TAXOPREXIN(P)
  • DHA-paclitaxel
  • Benzenepropanoic acid, β-(benzoylamino)-α-[[(4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaen-1-yl]oxy]-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclod...
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Found 2 products.
  • Dha-paclitaxel
    Biosynth
    + Info

    Dha-paclitaxel

    CAS:
    <p>Dha-paclitaxel is a synthetic, natural, and pharmacopoeia impurity standard. It is used as an analytical reference in HPLC to measure paclitaxel content. Dha-paclitaxel may be present in the drug product as a metabolite of paclitaxel. This impurity can be found in the urine or feces of patients who have received paclitaxel therapy.</p>
    Formula:C69H81NO15
    Purity:Min. 95%
    Molecular weight:1,164.40 g/mol

    Ref: 3D-ZHA79652

    1mg
    801.00€
    5mg
    2,077.00€
    10mg
    3,323.00€
    25mg
    6,230.00€
    50mg
    9,967.00€
  • DHA-paclitaxel
    Targetmol
    + Info

    DHA-paclitaxel

    CAS:
    <p>DHA-paclitaxel (Taxoprexin): omega-3-linked prodrug targeting tumors by inhibiting cell division &amp; inducing apoptosis with better pharmacokinetics.</p>
    Formula:C69H81NO15
    Color and Shape:Solid
    Molecular weight:1164.38

    Ref: TM-T70006