CAS 2002-35-9

2′-Deoxy-N6-methyladenosine

Description:

2′-Deoxy-N6-methyladenosine (CAS 2002-35-9) is a modified nucleoside that plays a significant role in various biological processes, particularly in the context of RNA and DNA methylation. It is a derivative of adenosine, where a methyl group is added to the nitrogen atom at the sixth position of the adenine base. This modification can influence gene expression and is involved in the regulation of various cellular functions. The presence of the 2′-deoxy ribose sugar distinguishes it from other nucleosides, making it a component of DNA rather than RNA. The methylation of nucleosides like 2′-deoxy-N6-methyladenosine is crucial for epigenetic regulation, impacting processes such as transcriptional regulation and chromatin structure. In terms of solubility, it is generally soluble in water and organic solvents, which facilitates its use in biochemical assays and research. Its study is important for understanding the mechanisms of gene regulation and the potential implications in diseases such as cancer.

Formula: C₁₁H₁₅N₅O₃

InChI: InChI=1/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1

InChI key: InChIKey=DYSDOYRQWBDGQQ-XLPZGREQSA-N

SMILES: N(C)C1=C2C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)=NC=N1

Synonyms:

• 2'-Deoxy-N(6)-methyladenosine
• 2'-deoxy-N-methyladenosine
• 2′-Deoxy-N⁶-methyladenosine
• 6-(Methylamino)purine deoxyriboside
• Adenosine, 2'-deoxy-N-methyl-
• N(6)-Me-Dado
• N6-Methyl-2'-Deoxy-Adenosine
• N6-Methyl-2'-deoxyadenosine
• N⁶-Methyl-2′-deoxyadenosine
• N⁶-Methyldeoxyadenosine
• Nsc 66392
• N(6)-Methyl-2'-deoxyadenosine
• 2′-Deoxy-N6-methyladenosine
• N6-Me-dA
• (2R,3S,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolan-3-ol
• N6-Me-dAdo
• 6
• 2'-Deoxy-N
• (2R,3S,5R)-5-[6-(methylamino)purin-9-yl]-2-methylol-tetrahydrofuran-3-ol
• (2R,3S,5R)-2-(HydroxyMethyl)-5-(6-(MethylaMino)-9H-purin-9-yl)tetrahydrofuran-3-ol
• N6-Me-2'-deoxyadenosine
• -Methyladenosine
• -Me-dAdo
• 2'-Deoxy-N6-methyl-D-adenosine
• N6-Me-2'-dA
• N
• -Methyl-2'-deoxyadenosine

N6-Methyl-2'-deoxyadenosine, 99%

CAS: 2002-35-9

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₁H₁₅N₅O₃

Purity: 99%

Molecular weight: 265.27

Ref: 02-J64961

Adenosine, 2'-deoxy-N-methyl-

CAS: 2002-35-9

Formula: C₁₁H₁₅N₅O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 265.2685

Ref: IN-DA002CM4

N-6-Methyl-2-deoxyadenosine

CAS: 2002-35-9

N-6-Methyl-2-deoxyadenosine

Purity: 95%

Molecular weight: 265.27g/mol

Ref: 54-OR1035917

2''-Deoxy-N6-methyladenosine

CAS: 2002-35-9

Formula: C₁₁H₁₅N₅O₃

Purity: ≥ 99.0%

Color and Shape: White powder

Molecular weight: 265.27

Ref: 7W-GN1250

N6-METHYL-2'-DEOXYADENOSINE

CAS: 2002-35-9

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 265.27301025390625

Ref: 10-F334242

N6-Methyldeoxyadenosine

CAS: 2002-35-9

N6-Methyldeoxyadenosine is an adenine nucleoside analogue exhibiting antimalarial activity against Plasmodium falciparum, with an IC₃₇ of 10 μM.

Formula: C₁₁H₁₅N₅O₃

Color and Shape: Solid

Molecular weight: 265.27

Ref: TM-TNU0419

2'-Deoxy-N-methyladenosine-d3

Controlled Product

CAS: 2002-35-9

Applications 2'-Deoxy-N-methyladenosine-d3 is the labelled form of 2'-Deoxy-N-methyladenosine (D242415). 2'-Deoxy-N-methyladenosine plays role in catalytic activity and may promote proper folding of A730 loop.
References Lafontaine, D. A., et al.: J. Mol. Biol., 323, 23-34 (2002)

Formula: C₁₁H₁₂D₃N₅O₃

Color and Shape: Neat

Molecular weight: 268.29

Ref: TR-D242417

2'-Deoxy-N-methyladenosine

Controlled Product

CAS: 2002-35-9

Applications 2'-Deoxy-N-methyladenosine plays role in catalytic activity and may promote proper folding of A730 loop.
References Lafontaine, D. A., et al.: J. Mol. Biol., 323, 23-34 (2002)

Formula: C₁₁H₁₅N₅O₃

Color and Shape: Neat

Molecular weight: 265.27

Ref: TR-D242415

2'-Deoxy-N6-methyladenosine

CAS: 2002-35-9

2'-Deoxy-N6-methyladenosine (2DMA) is a nucleoside that has been found to inhibit the phosphorylation of p2y receptors in rat kidney cells. 2DMA inhibits the production of collagen, which may have a matrix effect on cells. Studies have shown that 2DMA can be used as a sample preparation reagent for nuclear DNA. It has also been shown to be effective at inhibiting transcription and replication of human mitochondrial DNA.

Formula: C₁₁H₁₅N₅O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 265.27 g/mol

Ref: 3D-ND06386