CAS 2004-06-0

6-Chloro-9-ribofuranosyl-9H-purine

Description:

6-Chloro-9-ribofuranosyl-9H-purine, commonly known as cladribine, is a synthetic purine nucleoside analog that exhibits significant biological activity. It features a ribofuranosyl sugar moiety attached to a purine base, specifically 9H-purine, with a chlorine substituent at the 6-position. This compound is primarily recognized for its role as an immunosuppressive agent, particularly in the treatment of certain hematological malignancies and autoimmune diseases. Cladribine is known to interfere with DNA synthesis and repair, leading to the selective depletion of lymphocytes, which is beneficial in conditions like multiple sclerosis. The compound is typically administered intravenously or orally, and its pharmacokinetics involve rapid distribution and metabolism. Its therapeutic efficacy is accompanied by potential side effects, including immunosuppression and increased risk of infections. Overall, 6-Chloro-9-ribofuranosyl-9H-purine is a crucial compound in modern medicine, particularly in oncology and immunology.

Formula: C₁₀H₁₁ClN₄O₄

InChI: InChI=1/C10H11ClN4O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2/t4-,6-,7-,10?/s2

InChI key: InChIKey=XHRJGHCQQPETRH-HRBNIKIZNA-N

SMILES: O[C@H]1C(N2C=3C(N=C2)=C(Cl)N=CN3)O[C@H](CO)[C@H]1O

Synonyms:

• 6-Chloro-9-ribofuranosyl-9H-purine
• 6-Chloropurine nucleoside
• 6-Chloropurine ribonucleoside
• 6-Chloropurine ribose
• 6-Chloropurine-9-¤-D-ribofuranoside
• 6-chloro-9-(beta-D-ribofuranosyl)-9H-purine
• 6-chloro-9-alpha-L-lyxofuranosyl-9H-purine
• 6-chloro-9-pentofuranosyl-9H-purine
• 9H-Purine, 6-chloro-9-ribofuranosyl-

6-Chloropurine riboside, 98%

CAS: 2004-06-0

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Sci

Formula: C₁₀H₁₁ClN₄O₄

Purity: 98%

Color and Shape: White to pale yellow, Solid

Molecular weight: 286.67

Ref: 02-J64612

9H-Purine, 6-chloro-9-ribofuranosyl-

CAS: 2004-06-0

Formula: C₁₀H₁₁ClN₄O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 286.6717

Ref: IN-DA002CQY

6-Chloropurine Riboside

CAS: 2004-06-0, 5399-87-1

Formula: C₁₀H₁₁ClN₄O₄

Purity: >97.0%(T)(HPLC)

Color and Shape: White to Orange to Green powder to crystal

Molecular weight: 286.67

Ref: 3B-C2206

6-Chloropurine riboside

CAS: 2004-06-0

6-Chloropurine riboside

Formula: C₁₀H₁₁ClN₄O₄

Purity: 97%

Color and Shape: faint yellow solid

Molecular weight: 286.67g/mol

Ref: 54-OR303362

6-Chloropurine Riboside extrapure

CAS: 2004-06-0

Formula: C₁₀H₁₁ClN₄O₄

Purity: min. 98%

Color and Shape: White to yellow to green, Crystalline powder

Molecular weight: 286.68

Ref: SR-57430