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CAS 200616-40-6

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Fmoc-N-Me-Glu(OtBu)-OH

Description:
Fmoc-N-Me-Glu(OtBu)-OH, also known as Fmoc-N-methyl-glutamic acid with a tert-butyl ester protecting group, is a derivative of glutamic acid commonly used in peptide synthesis and research. The Fmoc (9-fluorenylmethoxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions during peptide assembly. The N-methyl substitution enhances the compound's lipophilicity and can influence the conformational properties of peptides. The tert-butyl ester (OtBu) protects the carboxylic acid group, providing stability and preventing unwanted reactions during synthesis. This compound is typically white to off-white in appearance and is soluble in organic solvents such as dimethyl sulfoxide (DMSO) and dichloromethane, but less soluble in water. Its structure allows for the introduction of specific functionalities in peptide sequences, making it valuable in the development of pharmaceuticals and bioconjugates. As with many chemical substances, proper handling and storage are essential to maintain its integrity and reactivity.
Formula:C25H29NO6
InChI:InChI=1/C25H29NO6/c1-25(2,3)32-22(27)14-13-21(23(28)29)26(4)24(30)31-15-20-18-11-7-5-9-16(18)17-10-6-8-12-19(17)20/h5-12,20-21H,13-15H2,1-4H3,(H,28,29)/t21-/m0/s1
SMILES:CC(C)(C)OC(=O)CC[C@@H](C(=O)O)N(C)C(=O)OCC1c2ccccc2c2ccccc12
Synonyms:
  • (2S)-5-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonyl-methyl-amino)-5-oxo-pentanoic acid
  • Fmoc-N-methyl-L-glutamic acid 5-tert-butyl ester
  • FMOC-N-ME-GLUTAMIC ACID(OTBU)-OH
  • N-ALPHA-FMOC-N-ALPHA-METHYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
  • FMOC-L-MEGLU(TBU)-OH
  • FMOC-N-METHYL-L-GLUTAMIC ACID-GAMMA-T-BUTYL ESTER
  • FMOC-MEGLU(OTBU)-OH
  • N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER
  • N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-L-GLUTAMIC-ACID-GAMMA-TERT-BUTYL ESTER
  • FMOC-N-ME-GLU(OTBU)-OH
  • See more synonyms
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