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CAS 201049-78-7

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2-Desacetoxy Prasugrel

Description:
2-Desacetoxy Prasugrel, with the CAS number 201049-78-7, is a chemical compound that serves as an active metabolite of the antiplatelet medication Prasugrel. It is characterized by its role in inhibiting platelet aggregation, which is crucial for preventing thrombotic cardiovascular events. The compound features a thienopyridine structure, which is essential for its pharmacological activity. 2-Desacetoxy Prasugrel is known for its rapid metabolism and bioactivation, leading to the formation of its active form that irreversibly binds to the P2Y12 receptor on platelets. This binding prevents adenosine diphosphate (ADP) from activating platelets, thereby reducing the risk of clot formation. The compound is typically administered in conjunction with aspirin for enhanced antiplatelet effects. Its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are influenced by various factors, including genetic variations in metabolic enzymes. Overall, 2-Desacetoxy Prasugrel is significant in the context of cardiovascular therapy, particularly in patients undergoing percutaneous coronary interventions.
Formula:C18H18FNOS
Synonyms:
  • Prasugrel Desoxo Analogue
  • Ethanone, 1-cyclopropyl-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-fluorophenyl)-
  • Prasugrel HCl Desacetyloxy Impurity
  • 1-cyclopropyl-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)-2-(2-fluorophenyl)ethanone
  • Prasugrel Impurity 14
  • Prasugrel Desacetyloxy Impurity
  • 2-Desacetoxy Prasugrel
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  • 2-Desacetoxy Prasugrel
    TRC
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    2-Desacetoxy Prasugrel

    Controlled Product
    CAS:
    <p>Applications 2-Desacetoxy Prasugrel is a useful synthetic intermediate in the synthesis of Prasugrel (P701150, HCl); an antiplatelet agent.<br>References Wiviott, S.D., et al.: Circulation, 116, 2923 (2007); Satyanarayana Reddy, M., et al. PCT Int. Appl. WO 2011042918 A2 20110414. Apr 14, 2011; Zhu, G., et al. Faming Zhuanli Shenqing. CN 101531667 A 20090916. Sep 16, 2009<br></p>
    Formula:C18H18FNOS
    Color and Shape:Neat
    Molecular weight:294.324

    Ref: TR-D288250

    500mg
    1,530.00€