CAS 2011-67-8

Nimetazepam

Description:

Nimetazepam is a pharmaceutical compound classified as a benzodiazepine derivative, primarily used for its anxiolytic and sedative properties. It is known for its ability to enhance the effects of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA-A receptor, leading to increased sedation and relaxation. Nimetazepam is typically administered in tablet form and is indicated for the short-term treatment of insomnia and anxiety disorders. Its pharmacological effects include muscle relaxation, anticonvulsant activity, and amnesic properties. The substance has a relatively rapid onset of action, making it effective for acute management of anxiety and sleep disturbances. However, like other benzodiazepines, it carries a risk of dependence, tolerance, and withdrawal symptoms with prolonged use. Nimetazepam is subject to regulatory controls in many countries due to its potential for abuse and misuse. Its safety profile includes common side effects such as drowsiness, dizziness, and cognitive impairment, necessitating caution in activities requiring mental alertness.

Formula: C₁₆H₁₃N₃O₃

InChI: InChI=1S/C16H13N3O3/c1-18-14-8-7-12(19(21)22)9-13(14)16(17-10-15(18)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3

InChI key: InChIKey=GWUSZQUVEVMBPI-UHFFFAOYSA-N

SMILES: CN1C=2C(C(=NCC1=O)C3=CC=CC=C3)=CC(N(=O)=O)=CC2

Synonyms:

• 1,3-Dihydro-1-methyl-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one
• 1-Methyl-5-phenyl-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 1-Methyl-7-nitro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 1-Methyl-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2(3H)-one
• 1-Methyl-7-nitro-5-phenyl-3H-1,4-benzodiazepin-2-one
• 1-Methylnitrazepam
• 2H-1,4-Benzodiazepin-2-one, 1,3-dihydro-1-methyl-7-nitro-5-phenyl-
• Brn 0759813
• DEA No. 2837
• Elimin
• Erimin
• Hypnon
• Methylnitrazepam
• N-Methylmogadon
• N-Methylnitrazepam
• Nimetazam
• Nimetazepam [INN:JAN]
• Nimetazepamum
• Nimetazepamum [INN-Latin]
• Ro 5-3453
• S 1530
• Unii-4532264Kw6
• 5-24-04-00346 (Beilstein Handbook Reference)
• Nimetazepam

Nimetazepam

Controlled Product

CAS: 2011-67-8

Color and Shape: Neat

Ref: LP-NMT-1256

Nimetazepam

Controlled Product

CAS: 2011-67-8

Applications Sedative, hypnotic. Controlled substance.
References Inaba, et al.: Chem. Pharm. Bull., 19, 722 (1971), Sakai, S., et al.: Arzneim.-Forsch., 22, 534 (1972),

Formula: C₁₆H₁₃N₃O₃

Color and Shape: Neat

Molecular weight: 295.29

Ref: TR-N477800

Nimetazepam (1 mg/ml in Methanol)

Controlled Product

CAS: 2011-67-8

Formula: C₁₆H₁₃N₃O₃

Color and Shape: Single Solution

Molecular weight: 295.29

Ref: TR-KIT0230

Nimetazepam

Controlled Product

CAS: 2011-67-8

Nimetazepam is a benzodiazepine that is used as a sedative and hypnotic. Nimetazepam is chemically classified as a high-potency benzodiazepine. It has been shown to have an intermediate duration of action, with peak plasma levels occurring 2 hours after administration. Nimetazepam has pharmacokinetic properties that are similar to those of diazepam, which include rapid absorption from the gastrointestinal tract and high lipid solubility. The drug is excreted in the urine primarily as metabolites, with about 25% being excreted unchanged in the urine. This drug also has a number of side effects such as symptoms of chronic oral administration (e.g., weight loss) and trifluoroacetic acid-induced liver injury in rats. Nimetazepam undergoes intermolecular hydrogen bonding between its nitrogen atom and the alpha carbon atoms on adjacent molecules, which is one of the reasons for its structural analysis by

Formula: C₁₆H₁₃N₃O₃

Purity: Min. 95%

Molecular weight: 295.29 g/mol

Ref: 3D-FN26224