CAS 201541-53-9

Fluvastatin sodium salt hydrate

CAS: 201541-53-9

Fluvastatin is a statin that lowers blood cholesterol and triglycerides by inhibiting HMG-CoA reductase, an enzyme that plays a critical role in the synthesis of cholesterol. Fluvastatin has also been shown to reduce the incidence of myocardial infarction, and to reduce atherosclerotic lesions in animal models, reducing the incidence of cardiovascular disease. Fluvastatin also has been shown to inhibit the activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS), which may be related to its anti-inflammatory effects. Furthermore, through lowering blood cholesterol, Fluvastatin also inhibits tubulointerstitial injury and prevents renal damage caused by high concentrations of the lipid.

Formula: C₂₄H₂₇FNNaO₅

Purity: Min. 95%

Molecular weight: 451.5 g/mol

Ref: 3D-BIA54153

Fluvastatin sodium monohydrate

CAS: 201541-53-9

Fluvastatin (XU 62-320) sodium monohydrate, a fully synthetic competitive HMG-CoA reductase inhibitor, features an IC 50 of 8 nM. This compound also safeguards vascular smooth muscle cells from oxidative stress via the Nrf2-dependent antioxidant pathway [1] [2].

Formula: C₂₄H₂₇FNNaO₅

Color and Shape: Solid

Molecular weight: 451.46

Ref: TM-T86463