CAS 2016-88-8

Amiloride hydrochloride

Description:

Amiloride hydrochloride is a potassium-sparing diuretic primarily used in the treatment of hypertension and edema associated with congestive heart failure. It functions by inhibiting sodium reabsorption in the distal nephron of the kidneys, which helps to promote diuresis while minimizing potassium loss. The substance appears as a white to off-white crystalline powder, and it is soluble in water, making it suitable for oral administration. Its chemical formula is C6H8ClN5O, and it has a molecular weight of approximately 189.65 g/mol. Amiloride hydrochloride is often used in combination with other diuretics to enhance therapeutic efficacy and reduce the risk of hypokalemia. The compound is generally well-tolerated, but potential side effects may include hyperkalemia, gastrointestinal disturbances, and dizziness. As with any medication, it is essential to use amiloride hydrochloride under medical supervision to monitor for adverse effects and interactions with other drugs.

Formula: C₆H₈ClN₇O·ClH

InChI: InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H

InChI key: InChIKey=ACHKKGDWZVCSNH-UHFFFAOYSA-N

SMILES: C(NC(=N)N)(=O)C=1C(N)=NC(N)=C(Cl)N1.Cl

Synonyms:

• Amiloride Hydrochloride
• Amiloride HCl
• (3,5-diamino-6-chloropyrazin-2-yl)-N-(diaminomethylidene)oxomethanaminium
• 1-(3,5-Diamino-6-chloropyrazinecarboxyl)guanidine hydrochloride
• 2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, hydrochloride (1:1)
• 3,5-Diamino-N-(amino iminomethyl)-6-chloropyrazinecarboxamide hydrochloride
• Amilorid hydrochloride
• Amipramidine
• Amipramizide
• Amiprazide
• Colectril
• Guanamprazine hydrochloride
• Midamor
• MK-870 hydrochloride
• N-Amidino-3,5-diamino-6-chloropyrazinamide hydrochloride
• N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride
• N-amidino-3,5-diamino-6-chloropyrazinecarboxamide monohydrochloride
• N-amidino-3,5-diamino-6-chloropyrazinecarboxamide, monochlorhydrate
• N-Amidino-3,5-diamino-6-chlorpyrazincarboxamidmonohydrochlorid
• N-amidino-3,5-diamino-6-cloropirazinacarboxamida, monoclorhidrato
• Nilurid
• Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, monohydrochloride

Amiloride Hydrochloride

CAS: 2016-88-8, 2609-46-3

Formula: C₆H₈ClN₇O·HCl

Purity: >98.0%(HPLC)(N)

Color and Shape: Light yellow to Yellow to Green powder to crystal

Molecular weight: 266.09

Ref: 3B-A2599

Amiloride hydrochloride

CAS: 2016-88-8

Amiloride hydrochloride (Amiloride HCl) 是上皮钠通道和尿激酶型纤溶酶原激活物受体的抑制剂，也是 polycystin-2通道阻断剂。

Formula: C₆H₉Cl₂N₇O

Purity: 99.72% - 99.95%

Color and Shape: Physical Description Crystalline Solid Or Very Light Yellow Powder (Ntp 1992)

Molecular weight: 266.09

Ref: TM-T0175

Amiloride hydrochloride

CAS: 2016-88-8

Formula: C₆H₈ClN₇O·HCl

Purity: ≥ 98.0%

Color and Shape: Yellow to green powder or crystals

Molecular weight: 266.09

Ref: 7W-GK0403

Amiloride Hydrochloride Dihydrate

CAS: 2016-88-8

Formula: C₆H₈ClN₇O·HCl·2H₂O

Color and Shape: Light Yellow Solid

Molecular weight: 229.63 36.46 2*18.02

Ref: 4Z-A-401

N-Amido-3,5-diamino-6-chloropyrazine carboxamide hydrochloride dihydrate

CAS: 2016-88-8

Formula: C₆H₉Cl₂N₇O

Purity: 98.0%

Color and Shape: Yellow powder

Molecular weight: 266.09

Ref: 10-F019420

Amiloride Hydrochloride

CAS: 2016-88-8

Applications Sodium channel blocker. Diuretic.
References Paterson, J., et al.: Br. Med. J., 1, 422 (1968), Khan, K., et al.: J. Pharm. Pharmacol., 27, 48 (1975), Frank, S., et al.: J. Pharm. Sci., 64, 1585 (1975), Vidt, D., et al.: Pharmacotherapy, 1, 179 (1981),

Formula: C₆H₈ClN₇O·ClH

Color and Shape: Neat

Molecular weight: 266.09

Ref: TR-A578700