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CAS 2016-88-8

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Amiloride hydrochloride

Description:
Amiloride hydrochloride is a potassium-sparing diuretic primarily used in the treatment of hypertension and edema associated with congestive heart failure. It functions by inhibiting sodium reabsorption in the distal nephron of the kidneys, which helps to promote diuresis while minimizing potassium loss. The substance appears as a white to off-white crystalline powder, and it is soluble in water, making it suitable for oral administration. Its chemical formula is C6H8ClN5O, and it has a molecular weight of approximately 189.65 g/mol. Amiloride hydrochloride is often used in combination with other diuretics to enhance therapeutic efficacy and reduce the risk of hypokalemia. The compound is generally well-tolerated, but potential side effects may include hyperkalemia, gastrointestinal disturbances, and dizziness. As with any medication, it is essential to use amiloride hydrochloride under medical supervision to monitor for adverse effects and interactions with other drugs.
Formula:C6H8ClN7O·ClH
InChI:InChI=1S/C6H8ClN7O.ClH/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;/h(H4,8,9,13)(H4,10,11,14,15);1H
InChI key:InChIKey=ACHKKGDWZVCSNH-UHFFFAOYSA-N
SMILES:C(NC(=N)N)(=O)C=1C(N)=NC(N)=C(Cl)N1.Cl
Synonyms:
  • Amiloride Hydrochloride
  • Amiloride HCl
  • (3,5-diamino-6-chloropyrazin-2-yl)-N-(diaminomethylidene)oxomethanaminium
  • 1-(3,5-Diamino-6-chloropyrazinecarboxyl)guanidine hydrochloride
  • 2-Pyrazinecarboxamide, 3,5-diamino-N-(aminoiminomethyl)-6-chloro-, hydrochloride (1:1)
  • 3,5-Diamino-N-(amino iminomethyl)-6-chloropyrazinecarboxamide hydrochloride
  • Amilorid hydrochloride
  • Amipramidine
  • Amipramizide
  • Amiprazide
  • See more synonyms
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