CAS 2018-66-8: Benzyloxycarbonyl-L-leucine

Description: Benzyloxycarbonyl-L-leucine, commonly referred to as Z-Leu, is a derivative of the amino acid leucine, characterized by the presence of a benzyloxycarbonyl (Z) protecting group. This compound is typically utilized in peptide synthesis as a protecting group for the amino group of leucine, facilitating the formation of peptide bonds without interference from the amino group. Z-Leu is a white to off-white crystalline solid, and it is soluble in organic solvents such as methanol and dimethyl sulfoxide, but has limited solubility in water. The presence of the benzyloxycarbonyl group enhances the stability of the amino acid during chemical reactions, making it a valuable intermediate in the synthesis of more complex peptides and proteins. Additionally, Z-Leu can be deprotected under specific conditions, allowing for the regeneration of the free amino group for further reactions. Its CAS number, 2018-66-8, is used for identification in chemical databases and regulatory contexts. Overall, Benzyloxycarbonyl-L-leucine plays a significant role in organic chemistry and biochemistry, particularly in the field of peptide synthesis.

Formula: C₁₄H₁₉NO₄

InChI: InChI=1S/C14H19NO4/c1-10(2)8-12(13(16)17)15-14(18)19-9-11-6-4-3-5-7-11/h3-7,10,12H,8-9H2,1-2H3,(H,15,18)(H,16,17)/t12-/m0/s1

InChI key: InChIKey=USPFMEKVPDBMCG-LBPRGKRZSA-N

SMILES: O=C(OCC=1C=CC=CC1)NC(C(=O)O)CC(C)C

Synonyms:

• (2S)-2-[[(Benzyloxy)carbonyl]amino]-4-methylpentanoic acid
• (2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoate
• (2S)-4-Methyl-2-(phenylmethoxycarbonylamino)pentanoic acid
• (Benzyloxycarbonyl)leucine
• (Carbobenzoxy)leucine
• (Carbobenzyloxy)-<span class="text-smallcaps">L</span>-leucine
• <span class="text-smallcaps">L</span>-(Carbobenzyloxy)leucine
• <span class="text-smallcaps">L</span>-Leucine, N-[(phenylmethoxy)carbonyl]-
• <span class="text-smallcaps">L</span>-N-(Benzyloxycarbonyl)leucine
• Benzyloxycarbonyl-<span class="text-smallcaps">L</span>-leucine
• CBZ-<span class="text-smallcaps">L</span>-leucine
• Carbobenzoxy-<span class="text-smallcaps">L</span>-leucine
• Cbz-L-leucine
• Leucine, N-carboxy-, N-benzyl ester
• Leucine, N-carboxy-, N-benzyl ester, <span class="text-smallcaps">L</span>-
• N-(Benzyloxycarbonyl)-<span class="text-smallcaps">L</span>-leucine
• N-(Benzyloxycarbonyl)leucine
• N-(Carbobenzoxy)leucine
• N-Carbobenzoxy-<span class="text-smallcaps">L</span>-leucine
• N-Carbobenzyloxy-<span class="text-smallcaps">L</span>-leucine
• N-Carboxy-<span class="text-smallcaps">L</span>-leucine N-benzyl ester
• N-[(Phenylmethoxy)carbonyl]-<span class="text-smallcaps">L</span>-leucine
• N-[(benzyloxy)carbonyl]-D-leucine
• N-[(benzyloxy)carbonyl]-L-leucine
• N-[(benzyloxy)carbonyl]leucine
• N-cbz-l-leucine
• NSC 60039
• Nα-Benzyloxycarbonyl-L-leucine
• Z-Leu-OH
• z-Leu
• L-Leucine, N-[(phenylmethoxy)carbonyl]-
• Leucine, N-carboxy-, N-benzyl ester, L-
• N-[(Phenylmethoxy)carbonyl]-L-leucine
• Benzyloxycarbonyl-L-leucine

N-Benzyloxycarbonyl-L-leucine

CAS: 2018-66-8

• Formula: C₁₄H₁₉NO₄
• Purity: >96.0%(T)
• Color and Shape: Colorless to Light yellow clear liquid
• Molecular weight: 265.31

Z-Leu-OH (oil)

CAS: 2018-66-8

Bachem ID: 4000522.

• Formula: C₁₄H₁₉NO₄
• Purity: > 98%
• Color and Shape: White Oily
• Molecular weight: 265.31

N-Carbobenzyloxy-L-leucine

CAS: 2018-66-8

• Formula: C₁₄H₁₉NO₄
• Purity: 97%
• Color and Shape: Liquid
• Molecular weight: 265.30496000000005

Z-Leu-OH

CAS: 2018-66-8

• Formula: C₁₄H₁₉NO₄
• Purity: ≥ 96.0%
• Color and Shape: Light yellow liquid
• Molecular weight: 265.30

N-Cbz-L-Leucine

CAS: 2018-66-8

N-Cbz-L-Leucine (N-[(Phenylmethoxy)carbonyl]-L-leucine) is a leucine derivative, a commonly used amino acid protecting group.

• Formula: C₁₄H₁₉NO₄
• Purity: 99.59%
• Color and Shape: Liquid
• Molecular weight: 265.3

Cbz-Leucine

CAS: 2018-66-8

• Purity: 98.0%
• Color and Shape: Liquid
• Molecular weight: 265.3089904785156

N-Benzyloxycarbonyl-L-leucine

CAS: 2018-66-8

N-Benzyloxycarbonyl-L-leucine is a peptidomimetic that has been shown to be effective against P. aeruginosa. The …

• Formula: C₁₄H₁₉NO₄
• Purity: Min. 98 Area-%
• Color and Shape: Clear Liquid
• Molecular weight: 265.31 g/mol

Z-L-Leucine extrapure, 98%

CAS: 2018-66-8

• Formula: C₁₄H₁₉NO₄
• Purity: min. 98%
• Color and Shape: Clear, Colourless to pale yellow, Viscous liquid
• Molecular weight: 265.30

N-Cbz-L-leucine

CAS: 2018-66-8

Applications N-Cbz-L-Leucine is an N-Cbz-protected form of L-Leucine (L330110). L-Leucine is an essential amino acid …

• Formula: C₁₄H₁₉NO₄
• Color and Shape: Neat
• Molecular weight: 265.30

N-Benzyloxycarbonyl-L-leucine, 98% (dry wt.), may cont. up to ca 5% solvent

CAS: 2018-66-8

It is employed as a reactant for peptide-based preparation of potential antitumor agents, preparation of …

• Formula: C₁₄H₁₉NO₄
• Purity: 98%
• Color and Shape: Clear, colorless to pale yellow, Viscous liquid
• Molecular weight: 265.31