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CAS 2019163-02-9

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  • Cernuumolide J
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    Cernuumolide J

    CAS:
    <p>Cernuumolide J (TMJ-105) functions as a JAK2/STAT3 inhibitor and exhibits potent activity against HEL leukemia cells by inhibiting their growth in both time-dependent and concentration-dependent manners, with an IC 50 value of 1.79 μM. This compound effectively induces G2/M phase arrest and apoptosis by downregulating the phosphorylation of JAK2, STAT3, and Erk, while simultaneously upregulating the phosphorylation of JNK and p38 MAPK. Cernuumolide J holds potential for research applications in anti-cancer therapy.</p>
    Formula:C24H34O8
    Color and Shape:Solid
    Molecular weight:450.52

    Ref: TM-T200239