CAS 202121-03-7

Prion Protein (118-135) (human)

Description:

Prion Protein (118-135) (human), associated with the CAS number 202121-03-7, is a peptide fragment derived from the prion protein (PrP), which is encoded by the PRNP gene in humans. This fragment corresponds to a specific region of the full-length prion protein, which is known for its role in neurodegenerative diseases, such as Creutzfeldt-Jakob disease and other prion diseases. The peptide is characterized by its ability to adopt multiple conformations, including alpha-helical and beta-sheet structures, which are crucial for its biological function and pathogenicity. Prion proteins are typically glycosylated and can undergo post-translational modifications, influencing their stability and interactions with other cellular components. The aggregation of misfolded prion proteins is a hallmark of prion diseases, leading to neurotoxicity and the formation of amyloid plaques. Research on this peptide fragment is significant for understanding prion biology and developing therapeutic strategies against prion-related disorders.

Formula: C₆₈H₁₁₂N₁₈O₂₂S₂

Synonyms:

• H-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-Gly-Tyr-Met-Leu-Gly-Ser-Ala-Met-Ser-OH
• ALA-GLY-ALA-VAL-VAL-GLY-GLY-LEU-GLY-GLY-TYR-MET-LEU-GLY-SER-ALA-MET-SER
• L-Serine, L-alanylglycyl-L-alanyl-L-valyl-L-valylglycylglycyl-L-leucylglycylglycyl-L-tyrosyl-L-methionyl-L-leucylglycyl-L-seryl-L-alanyl-L-methionyl-
• PRION PROTEIN (118-135) (HUMAN)
• PRION PROTEIN FRAGMENT 118-135 HUMAN

Prion Protein (118-135) (human) trifluoroacetate salt

CAS: 202121-03-7

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Formula: C₆₈H₁₁₂N₁₈O₂₂S₂

Purity: Min. 95%

Molecular weight: 1,597.86 g/mol

Ref: 3D-FP109214