CAS 20235-78-3

1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one

Description:

1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, with the CAS number 20235-78-3, is a nucleoside analog characterized by its unique structural features. This compound consists of a ribofuranosyl sugar moiety linked to a thioxo-dihydropyrimidinone base, which contributes to its potential biological activity. The thioxo group enhances its reactivity and may influence its interaction with biological targets, such as enzymes or nucleic acids. The presence of the ribofuranosyl unit suggests that it may mimic natural nucleosides, potentially allowing it to participate in biochemical processes. This compound has garnered interest in medicinal chemistry for its potential antiviral or anticancer properties, as modifications to nucleosides often lead to enhanced therapeutic effects. Its solubility, stability, and reactivity can vary based on environmental conditions, making it a subject of study in drug development and biochemical research. Overall, 1-beta-D-ribofuranosyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one represents a significant area of exploration in the field of nucleoside chemistry.

Formula: C₉H₁₂N₂O₅S

InChI: InChI=1/C9H12N2O5S/c12-3-4-6(14)7(15)8(16-4)11-2-1-5(13)10-9(11)17/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,17)/t4-,6-,7-,8-/m1/s1

SMILES: c1cn([C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O)c(=S)nc1O

Synonyms:

• 2-Thiouridine

2-Thiouridine

CAS: 20235-78-3

Formula: C₉H₁₂N₂O₅S

Purity: >98.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 260.26

Ref: 3B-T4108

Uridine, 2-thio-

CAS: 20235-78-3

Formula: C₉H₁₂N₂O₅S

Purity: 97%

Color and Shape: Solid

Molecular weight: 260.2670

Ref: IN-DA002875

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

CAS: 20235-78-3

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-Yl)-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

Purity: 95%

Molecular weight: 260.27g/mol

Ref: 54-OR1025864

2-Thiouridine

CAS: 20235-78-3

2-Thiouridine (s2U) stabilizes U:A pairs in tRNAs, weakens U:G wobbles, and aids RNA research and engineering.

Formula: C₉H₁₂N₂O₅S

Color and Shape: Solid

Molecular weight: 260.27

Ref: TM-T35656

2-Thiouridine

CAS: 20235-78-3

Formula: C₉H₁₂N₂O₅S

Molecular weight: 260.26

Ref: 4Z-U-0147

2-Thiouridine

CAS: 20235-78-3

Formula: C₉H₁₂N₂O₅S

Color and Shape: White to light-yellow powder or crystals

Molecular weight: 260.26

Ref: 7W-GN9592

2-Thiouridine

Controlled Product

CAS: 20235-78-3

Applications Modified nucleotide, essential for normal cell growth in some bacterial species. This compound is also able to chelate several metal ions.
References Ikeuchi, Y., et al.: Mol. Cell, 21, 97 (2006), Odani, A., et al.: J. Inorg. Biochem., 101, 727 (2007), Wohlgamuth-Benedum, J., et al.: J. Biol. Chem., 284, 23947 (2009),

Formula: C₉H₁₂N₂O₅S

Color and Shape: Neat

Molecular weight: 260.27

Ref: TR-T384000

2-Thiouridine

CAS: 20235-78-3

2-Thiouridine is a uridine derivative that acts as a precursor for protein synthesis. It is synthesized from 2-amino-5-thiazole carboxylic acid and uracil in two steps, first with the formation of 2-thiouridine monophosphate and then with the conversion to 2-thiouridine diphosphate. The synthesis of 2-thiouridine is catalyzed by the enzyme uridine phosphorylase, which converts it to uridine monophosphate. 2-Thiouridine has been shown to have immunomodulatory effects in cell culture systems and animal models. These effects are believed to be due to its ability to act as an inhibitor of fatty acid synthase, which generates fatty acids from acetyl CoA. This process prevents the production of prostaglandins and leukotrienes, thereby reducing inflammation.

Formula: C₉H₁₂N₂O₅S

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 260.27 g/mol

Ref: 3D-NT02881

2-THIOURIDINE

CAS: 20235-78-3

Formula: C₉H₁₂N₂O₅S

Purity: 95%

Color and Shape: Solid

Molecular weight: 260.26

Ref: 10-F512990