CAS 202409-33-4
:Etoricoxib
Description:
Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, primarily used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and acute pain. Its chemical formula is C18H15N3O4S, and it features a sulfonamide group, which contributes to its pharmacological activity. Etoricoxib exhibits a high affinity for COX-2, leading to reduced production of prostaglandins, which are mediators of inflammation and pain. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Common side effects may include gastrointestinal issues, cardiovascular risks, and potential renal effects, similar to other NSAIDs. Etoricoxib is contraindicated in certain populations, such as those with a history of cardiovascular disease or severe renal impairment. Overall, its targeted action on COX-2 makes it a valuable option in pain management, though careful consideration of its safety profile is essential in clinical use.
Formula:C18H15ClN2O2S
InChI:InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3
InChI key:InChIKey=MNJVRJDLRVPLFE-UHFFFAOYSA-N
SMILES:ClC1=CC(=C(N=C1)C=2C=CC(C)=NC2)C3=CC=C(S(C)(=O)=O)C=C3
Synonyms:- 2,3′-Bipyridine, 5-chloro-6′-methyl-3-[4-(methylsulfonyl)phenyl]-
- 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
- 5-Chloro-6'-Methyl-3-[4-(Methylsulfonyl)Phenyl]-2,3'-Bipyridine
- Algix
- Arcoxia
- Etobrix
- Etocox
- Etosaid
- Etoxib
- Etropain
- Kingcox
- Mk 0663
- Mk 663
- Nucoxia
- Tauxib
- Torcoxia
- See more synonyms
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Found 17 products.
2,3'-Bipyridine, 5-chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-
CAS:Formula:C18H15ClN2O2SPurity:98%Color and Shape:SolidMolecular weight:358.8419Ref: IN-DA002878
1g80.00€5g155.00€10g297.00€1kgTo inquire100g558.00€10mg33.00€500gTo inquire100mg36.00€250mg44.00€Etoricoxib
CAS:<p>Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties.</p>Formula:C18H15ClN2O2SPurity:99.68%Color and Shape:Off-White PowderMolecular weight:358.84Etoricoxib
CAS:Formula:C18H15ClN2O2SPurity:≥ 98.5% (dried basis)Color and Shape:White to off-white or pale yellow crystalline powderMolecular weight:358.84Etoricoxib-13C-d3
CAS:Formula:C1713CH12D3ClN2O2SColor and Shape:White To Off-White SolidMolecular weight:362.85Etoricoxib
CAS:Formula:C18H15ClN2O2SPurity:>95.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:358.84Etoricoxib
CAS:Controlled ProductFormula:C18H15ClN2O2SColor and Shape:Off-WhiteMolecular weight:358.84Etoricoxib-d6
CAS:Controlled Product<p>Applications Etoricoxib-d6 is the labelled analog of Etoricoxib (E934100), a specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>Formula:C18H9D6ClN2O2SColor and Shape:NeatMolecular weight:364.885-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
CAS:Controlled Product<p>Etoricoxib is a cyclooxygenase-2 (COX-2) inhibitor, which is a type of nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the enzyme COX-2 that is involved in the production of certain hormones called prostaglandins. These hormones are involved in the inflammation (swelling and heat) associated with conditions such as arthritis. By blocking the action of the COX-2 enzyme, etoricoxib reduces the production of prostaglandins and thus, reduces the inflammation and pain. It has been observed that Etoricoxib shows a higher selectivity for COX-2 over COX-1 in diverse studies, with a COX-1/COX-2 IC50 ratio of 344 for in vitro assays, and it is involved in the modulation of NF-ΚB/COX-2/PGE2 signaling.</p>Formula:C18H15ClN2O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:358.84 g/molEtoricoxib - Bio-X ™
CAS:Controlled Product<p>Etoricoxib is a cyclooxygenase-2 (COX-2) inhibitor, which is a type of nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the enzyme COX-2 that is involved in the production of certain hormones called prostaglandins. These hormones are involved in the inflammation (swelling and heat) associated with conditions such as arthritis. By blocking the action of the COX-2 enzyme, Etoricoxib reduces the production of prostaglandins and thus, reduces the inflammation and pain. <br>Etoricoxib is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.</p>Formula:C18H15ClN2O2SPurity:Min. 95%Color and Shape:PowderMolecular weight:358.84 g/molEtoricoxib-13C,d3
CAS:Controlled ProductFormula:CC17D3H12ClN2O2SColor and Shape:NeatMolecular weight:362.853Etoricoxib-d9
CAS:Controlled ProductFormula:C18D9H6ClN2O2SColor and Shape:NeatMolecular weight:367.897
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