CAS 202409-33-4

Etoricoxib

Description:

Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor, primarily used as a nonsteroidal anti-inflammatory drug (NSAID) for the treatment of pain and inflammation associated with conditions such as osteoarthritis, rheumatoid arthritis, and acute pain. Its chemical formula is C18H15N3O4S, and it features a sulfonamide group, which contributes to its pharmacological activity. Etoricoxib exhibits a high affinity for COX-2, leading to reduced production of prostaglandins, which are mediators of inflammation and pain. The substance is typically administered orally and has a relatively long half-life, allowing for once-daily dosing. Common side effects may include gastrointestinal issues, cardiovascular risks, and potential renal effects, similar to other NSAIDs. Etoricoxib is contraindicated in certain populations, such as those with a history of cardiovascular disease or severe renal impairment. Overall, its targeted action on COX-2 makes it a valuable option in pain management, though careful consideration of its safety profile is essential in clinical use.

Formula: C₁₈H₁₅ClN₂O₂S

InChI: InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6-13)24(2,22)23/h3-11H,1-2H3

InChI key: InChIKey=MNJVRJDLRVPLFE-UHFFFAOYSA-N

SMILES: ClC1=CC(=C(N=C1)C=2C=CC(C)=NC2)C3=CC=C(S(C)(=O)=O)C=C3

Synonyms:

• 2,3′-Bipyridine, 5-chloro-6′-methyl-3-[4-(methylsulfonyl)phenyl]-
• 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl)pyridine
• 5-Chloro-6'-Methyl-3-[4-(Methylsulfonyl)Phenyl]-2,3'-Bipyridine
• Algix
• Arcoxia
• Etobrix
• Etocox
• Etosaid
• Etoxib
• Etropain
• Kingcox
• Mk 0663
• Mk 663
• Nucoxia
• Tauxib
• Torcoxia

Etoricoxib-13C,d3

Controlled Product

CAS: 202409-33-4

Formula: CC₁₇D₃H₁₂ClN₂O₂S

Color and Shape: Neat

Molecular weight: 362.853

Ref: TR-E934104