CAS 20244-86-4
:7-Methylguanosine
Description:
7-Methylguanosine is a modified nucleoside that plays a crucial role in various biological processes, particularly in RNA metabolism. It is characterized by the presence of a methyl group at the nitrogen-7 position of the guanine base, which distinguishes it from standard guanosine. This modification is significant in the context of RNA stability and function, as it is involved in the capping of messenger RNA (mRNA) molecules, thereby protecting them from degradation and facilitating their translation. The chemical formula of 7-Methylguanosine reflects its composition of carbon, hydrogen, nitrogen, and oxygen atoms, typical of nucleosides. Its structure includes a ribose sugar linked to the modified guanine base. 7-Methylguanosine is found in various types of RNA, including mRNA and certain small RNAs, and is essential for proper gene expression regulation. Additionally, it has implications in research and therapeutic applications, particularly in understanding RNA processing and the development of RNA-based drugs.
Formula:C11H16N5O5
InChI:InChI=1S/C11H15N5O5/c1-15-3-16(8-5(15)9(20)14-11(12)13-8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2-,12,13,14,20)/p+1/t4-,6-,7-,10-/m1/s1
InChI key:InChIKey=OGHAROSJZRTIOK-KQYNXXCUSA-O
SMILES:C[N+]=1C2=C(N(C1)[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)NC(N)=NC2=O
Synonyms:- 1H-Purinium, 2-amino-6,9-dihydro-7-methyl-6-oxo-9-beta-D-ribofuranosyl-
- 1H-Purinium, 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
- 2-Amino-6,9-dihydro-7-methyl-6-oxo-9-beta-D-ribofuranosyl-1H-purinium
- 2-amino-7-methyl-9-beta-D-ribofuranosyl-7H-purin-9-ium-6-olate
- Guanosine, 7-methyl-
- N<sup>7</sup>-Methylguanosine
- Purinium, 2-amino-1,6-dihydro-7-methyl-6-oxo-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
- Purinium, 2-amino-1,6-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-
- 1H-Purinium, 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-
- 7-Methylguanosine
- N7-Methylguanosine
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Found 8 products.
7-Methylguanosine
CAS:Formula:C11H15N5O5Purity:>85.0%(HPLC)(qNMR)Color and Shape:White to Light yellow powder to crystalMolecular weight:297.277-Methylguanosine
CAS:7-Methylguanosine is a novel cNIIIB nucleotidase inhibitor (IC50 : 87.8 ± 7.5 μM).Formula:C11H16N5O5Purity:98.11%Color and Shape:SolidMolecular weight:298.28N7-Methylguanosine
CAS:<p>N-7-Methylguanosine is a nucleotide that has potent anti-viral activity. It inhibits viral replication by binding to the effector proteins of a virus and preventing translation, transcriptional regulation, and other biochemical processes. N7-Methylguanosine also binds to the x-ray crystal structures of the viral genome and blocks the binding of RNA polymerase to DNA. This drug can be used as an antiviral agent for the treatment of HIV infection and hepatitis B infection. N7-Methylguanosine is not active against some viruses such as herpes simplex virus type 1 or 2, influenza virus type A/B, or rhinovirus type 2.<br>N7-Methylguanosine has been shown to have an effect on body mass index in humans by reducing weight gain in patients with metabolic syndrome. It also has an enzyme form that can be used for therapeutic use in human serum.</p>Formula:C11H15N5O5Purity:Min. 95%Color and Shape:White PowderMolecular weight:297.27 g/mol7-Methylguanosine
CAS:Controlled Product<p>Stability Very Hyroscopic<br>Applications 7-Methylguanosine is used as a biomarker for some types of cancer.<br>References Reynaud, C., et al.: Cancer Lett., 255, 1991<br></p>Formula:C11H15N5O5Color and Shape:White SolidMolecular weight:297.277-Methyl-d3-guanosine
CAS:Controlled Product<p>Applications 7-Methyl-d3-guanosine is a useful isotopically labeled compound of 7-Methylguanosine (M311835)<br></p>Formula:C11D3H12N5O5Color and Shape:Off-WhiteMolecular weight:301.294
