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CAS 20283-69-6

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Niddamycin

Description:
Niddamycin is a naturally occurring antibiotic that belongs to the class of compounds known as macrolides. It is produced by the fermentation of certain strains of Streptomyces bacteria. Niddamycin exhibits antibacterial properties, primarily targeting Gram-positive bacteria, and is particularly effective against strains that are resistant to other antibiotics. The compound functions by inhibiting protein synthesis in bacterial cells, thereby preventing their growth and reproduction. Niddamycin has a complex molecular structure characterized by a large lactone ring, which is typical of macrolide antibiotics. Its pharmacological profile includes a relatively low toxicity to human cells, making it a candidate for therapeutic applications. However, like many antibiotics, the emergence of resistance can limit its effectiveness. Research into Niddamycin continues to explore its potential uses in treating various bacterial infections, as well as its mechanisms of action and interactions with other drugs. Overall, Niddamycin represents an important compound in the field of antimicrobial research and development.
Formula:C40H65NO14
InChI:InChI=1/C40H65NO14/c1-22(2)18-30(45)53-38-26(6)51-32(21-40(38,7)48)54-35-25(5)52-39(34(47)33(35)41(8)9)55-36-27(16-17-42)19-23(3)28(43)15-13-11-12-14-24(4)50-31(46)20-29(44)37(36)49-10/h11-13,15,17,22-27,29,32-39,44,47-48H,14,16,18-21H2,1-10H3/b12-11+,15-13+
InChI key:InChIKey=SSANHLOZXYEHCY-AMGMOTLZSA-N
SMILES:O([C@H]1[C@@H](CC=O)C[C@@H](C)C(=O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]1OC)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CC(C)C)=O)[C@H](C)O3)[C@@H](C)O2
Synonyms:
  • Niddamycin B
  • Leucomycin V, 9-deoxy-9-oxo-, 4B-(3-methylbutanoate)
  • Oxacyclohexadecane, leucomycin V deriv.
  • 3-Deacetylcarbomycin B
  • 6-{[4-(dimethylamino)-5-hydroxy-6-{[(11E,13E)-4-hydroxy-5-methoxy-9,16-dimethyl-2,10-dioxo-7-(2-oxoethyl)oxacyclohexadeca-11,13-dien-6-yl]oxy}-2-methyltetrahydro-2H-pyran-3-yl]oxy}-4-hydroxy-2,4-dimethyltetrahydro-2H-pyran-3-yl 3-methylbutanoate (non-preferred name)
  • Niddamycin
  • F3463
  • F 3463
  • F-3463
  • 9-Deoxy-9-oxoleucomycin V 4''-(3-methylbutanoate)
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