CAS 20290-10-2
:Morphine 6-glucuronide
Description:
Morphine 6-glucuronide (M6G) is an active metabolite of morphine, formed through the glucuronidation process in the liver. It is characterized by its chemical structure, which includes a morphinan backbone modified by a glucuronic acid moiety at the 6-position. M6G is known for its potent analgesic properties, often exhibiting a higher affinity for opioid receptors compared to morphine itself, particularly the mu-opioid receptor. This compound is water-soluble, which enhances its bioavailability when administered. M6G is primarily excreted through the kidneys, and its pharmacokinetics can be influenced by factors such as liver function and concurrent medications. Clinically, it is utilized in pain management, especially in patients who may not tolerate morphine due to side effects. Additionally, M6G has a lower potential for causing certain side effects associated with morphine, such as respiratory depression, making it a valuable option in opioid therapy. Understanding its characteristics is crucial for optimizing pain management strategies in clinical settings.
Formula:C23H27NO9
InChI:InChI=1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1
InChI key:InChIKey=GNJCUHZOSOYIEC-GAROZEBRSA-N
SMILES:O([C@@H]1[C@]2([C@]34C=5C(O2)=C(O)C=CC5C[C@]([C@@]3(C=C1)[H])(N(C)CC4)[H])[H])[C@@H]6O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]6O
Synonyms:- (5alpha,6alpha)-3-hydroxy-17-methyl-7,8-didehydro-4,5-epoxymorphinan-6-yl beta-D-glucopyranosiduronic acid
- Glucopyranosiduronic acid, 7,8-didehydro-4,5-alpha-epoxy-3-hydroxy-17-methylmorphinan-6-alpha-yl-, beta-D-
- Glucopyranosiduronic acid, 7,8-didehydro-4,5α-epoxy-3-hydroxy-17-methylmorphinan-6α-yl, β-<span class="text-smallcaps">D</span>-
- Morphinan, β-<span class="text-smallcaps">D</span>-glucopyranosiduronic acid deriv.
- Morphinan-3-ol, 7,8-didehydro-4,5α-epoxy-6α-(β-<span class="text-smallcaps">D</span>-glucopyranuronosyloxy)-17-methyl-
- Morphine 6-O-glucuronide
- Morphine 6-beta-D-glucopyranosiduronide
- Morphine 6-β-<span class="text-smallcaps">D</span>-glucopyranosiduronide
- Morphine 6-β-<span class="text-smallcaps">D</span>-glucuronide
- Morphine glucuronide
- Morphine-6-glucuronide
- beta-D-Glucopyranosiduronic acid, (5alpha,6alpha)-7,8-didehydro-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-yl
- β-<span class="text-smallcaps">D</span>-Glucopyranosiduronic acid, (5α,6α)-7,8-didehydro-4,5-epoxy-3-hydroxy-17-methylmorphinan-6-yl
- Morphinan-3-ol, 7,8-didehydro-4,5α-epoxy-6α-(β-D-glucopyranuronosyloxy)-17-methyl-
- Glucopyranosiduronic acid, 7,8-didehydro-4,5α-epoxy-3-hydroxy-17-methylmorphinan-6α-yl, β-D-
- Morphinan, β-D-glucopyranosiduronic acid deriv.
- See more synonyms
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Found 8 products.
Morphine-6-β-D-glucuronide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Controlled Substance. Major metabolite of Morphine that is a potent opioid receptor agonist. Analgesic (narcotic).<br>References Frances, B., et al.: J. Pharmacol. Exp. Ther, 262, 25 (1992), Wu, D., et al.: Drug Metab. Dispos., 25, 768 (1997), Krzanowska, E.K., et al.: Brain Res., 799, 329 (1998),<br></p>Formula:C23H27NO9Color and Shape:White To Light BeigeMolecular weight:461.46Morphine 6-β-D-Glucuronide (100μg/ml in Methanol:Water)
CAS:Controlled ProductFormula:C23H27NO9Color and Shape:Single SolutionMolecular weight:461.46Morphine 6-β-D-Glucuronide (1.0 mg/mL in Water:Methanol 80:20)
CAS:Controlled ProductFormula:C23H27NO9Color and Shape:Single SolutionMolecular weight:461.46
