CAS 202933-49-1

H-Ser-Leu-Ile-Gly-Lys-Val-Oh

Description:

The chemical substance known as H-Ser-Leu-Ile-Gly-Lys-Val-OH, with the CAS number 202933-49-1, is a peptide composed of a sequence of amino acids. This peptide features a combination of hydrophilic and hydrophobic residues, which contributes to its potential biological activity and interactions. The presence of serine (Ser), leucine (Leu), isoleucine (Ile), glycine (Gly), lysine (Lys), and valine (Val) indicates a diverse range of properties, including the ability to participate in hydrogen bonding and hydrophobic interactions. The terminal hydroxyl group (OH) suggests that it may have enhanced solubility in aqueous environments. Peptides like this one can play significant roles in various biological processes, including signaling pathways and enzyme functions. Additionally, the specific sequence of amino acids can influence the peptide's conformation, stability, and reactivity, making it of interest in fields such as biochemistry, pharmacology, and biotechnology. Further studies would be necessary to elucidate its specific functions and applications.

PAR-2 (1-6) (human)

CAS: 202933-49-1

PAR-2 (1-6) (human) (SLIGKV), a peptide ligand, is a PAR-2 agonist [1] .

Formula: C₂₈H₅₃N₇O₈

Color and Shape: Solid

Molecular weight: 615.76

Ref: TM-T76650

H-Ser-Leu-Ile-Gly-Lys-Val-OH

CAS: 202933-49-1

H-Ser-Leu-Ile-Gly-Lys-Val-OH is a potent inhibitor of the enzyme soybean trypsin. It is a member of the class of chemical inhibitors that are active against enzymes that regulate cell signaling and inflammatory responses. H-Ser-Leu-Ile-Gly-Lys-Val-OH inhibits toll receptor signaling, which triggers an inflammatory response in cells. This compound has been shown to be effective in animal models for bowel disease and asthma. H Ser Leu Ile Gly Lys Val OH also has low potency, which may be due to its ability to form covalent bonds with other molecules, such as DNA polymerase.

Formula: C₂₈H₅₃N₇O₈

Purity: Min. 95%

Molecular weight: 615.76 g/mol

Ref: 3D-PAR-3938-PI

PAR-2 (1-6) (human) trifluoroacetate salt

CAS: 202933-49-1

PAR-2 is a cytosolic protein that is activated by calcium. PAR-2 activation induces the synthesis of prostaglandins and other inflammatory mediators, which stimulate the release of substances from cells such as cytokines and chemokines. PAR-2 also has an important role in cell proliferation, differentiation, apoptosis, and cancer development. PAR-2 activation is induced by proteases such as trypsin or soybean trypsin inhibitor. The trifluoroacetate salt form of PAR-2 (1-6) has been used to inhibit protease activity in colon cancer cells and prostate cancer cells.
PAR-2 (1-6) (human) trifluoroacetate salt H-Ser-Leu-Ile-Gly-Lys-Val-OH trifluoroacetate salt is a potent chemical inhibitor of trypsin activity with IC50 values of 0.5 µM for soybean trypsin inhibitor

Formula: C₂₈H₅₃N₇O₈

Purity: Min. 95%

Molecular weight: 615.76 g/mol

Ref: 3D-FP109441

PAR-2 (1-6) (human)

CAS: 202933-49-1

The PAR-2 agonist SLIGKV can be used for the investigation of receptor functions.

Formula: C₂₈H₅₃N₇O₈

Purity: 98.6%

Color and Shape: White Lyophilisate

Molecular weight: 615.77

Ref: 01-4033271