CAS 20306-75-6

N-Methylacetoacetamide

Description:

N-Methylacetoacetamide is an organic compound characterized by its amide functional group and a methyl substitution on the nitrogen atom. It features a molecular structure that includes both an acetamide and a ketone moiety, contributing to its reactivity and potential applications in organic synthesis. This compound typically appears as a colorless to pale yellow liquid or solid, depending on its purity and temperature. It is soluble in polar solvents such as water and alcohols, which enhances its utility in various chemical reactions. N-Methylacetoacetamide is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals, owing to its ability to participate in nucleophilic reactions. Additionally, it may exhibit biological activity, making it of interest in medicinal chemistry. Safety data indicates that, like many organic compounds, it should be handled with care, as it may pose health risks if inhaled or ingested. Proper laboratory practices and safety protocols are essential when working with this substance.

Formula: C₅H₉NO₂

InChI: InChI=1S/C5H9NO2/c1-4(7)3-5(8)6-2/h3H2,1-2H3,(H,6,8)

InChI key: InChIKey=ATWLCPHWYPSRBQ-UHFFFAOYSA-N

SMILES: C(CC(C)=O)(NC)=O

Synonyms:

• 2-Acetyl-N-methylacetamide
• Acetoacetamide, N-methyl-
• Butanamide, N-methyl-3-oxo-
• N-Methylacetamid
• N-Methylacetoacetamide
• N-methyl-3-oxobutanamide

N-Methylacetoacetamide (ca. 70% in Water)

CAS: 20306-75-6

Formula: C₅H₉NO₂

Color and Shape: Light yellow to Yellow to Orange clear liquid

Molecular weight: 115.13

Ref: 3B-M0657

N-Methyl-3-oxobutanamide

CAS: 20306-75-6

Formula: C₅H₉NO₂

Purity: %

Color and Shape: Liquid

Molecular weight: 115.1305

Ref: IN-DA0028O8

N-Methylacetoacetamide (70% in water)

CAS: 20306-75-6

N-Methylacetoacetamide (70% in water)

Formula: C₅H₉NO₂

Purity: ≥95%

Color and Shape: Pale Yellow Liquid

Molecular weight: 115.13g/mol

Ref: 54-OR54480

N-Methylacetoacetamide (ca. 70% in Water)

CAS: 20306-75-6

Formula: C₅H₉NO₂

Purity: 70% in Water

Color and Shape: Liquid, Clear

Molecular weight: 115.132

Ref: 10-F240984

N-Methylacetoacetamide (70% in aqueous solution)

Controlled Product

CAS: 20306-75-6

Applications N-Methylacetoacetamide is a starting material in the synthesis of 1-Carbamoyl-2-oxopropyl acetate with the aid (diacetoxyiodo)benzene (DIB) as the oxidant. Also, it is a reagent used in the synthesis of 10H-Phenothiazines, which possesses for their biological activity against the regulatory enzymes involved in inflammatory diseases.
References Liu, W., et al.: Beilstein J. Org. Chem., 7, 1436-1440 (2011); Sadanandam, Y. S., et al.: Eur. J. Med. Chem., 44, 197-202 (2009)

Formula: C₅H₉NO₂

Color and Shape: Single Solution

Molecular weight: 115.13

Ref: TR-M293225