CAS 203115-63-3

1H-​Pyrrole-​2,​5-​dione, 1,​1'-​(2,​2-​dimethyl-​1,​3-​propanediyl)​bis[3,​4-​dichloro- (9CI)

CAS: 203115-63-3

Formula: C₁₃H₁₀Cl₄N₂O₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 400.0415

Ref: IN-DA00BJQV

NSC 617145

CAS: 203115-63-3

NSC 617145

Purity: ≥98%

Molecular weight: 400.04g/mol

Ref: 54-BUP12234

NSC 617145

CAS: 203115-63-3

NSC 617145 (NSC617145) is an inhibitor of WRN helicase that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent

Formula: C₁₃H₁₀Cl₄N₂O₄

Purity: 99.72%

Color and Shape: Solid

Molecular weight: 400.04

Ref: TM-T9168

NSC 617145

Controlled Product

CAS: 203115-63-3

Applications NSC 617145 is ahelicase inhibitor used in the treatment of Werner syndrome helicase and acts synergistically with Mitomycin C (M371900), an antitumor antibiotic. It is used as antineoplastic.
References Kinoshita, S., et al.: J. Med. Chem., 14, 13 (1971), Beijnen, J.H., et al.: Anal. Profiles Drug Subs., 16, 361 (1986),

Formula: C₁₃H₁₀Cl₄N₂O₄

Color and Shape: Neat

Molecular weight: 400.04

Ref: TR-N900535

NSC 617145

CAS: 203115-63-3

NSC 617145 is a molecule that inhibits leukemia inhibitory factor (LIF) activity by binding to the receptor LIFR. It has been shown to have an apoptotic effect on cells and may be a potential drug target for the treatment of cancer. This compound also has pro-apoptotic properties and can induce mitochondrial membrane depolarization, leading to cell death. NSC 617145 has also been shown to inhibit the production of epidermal growth factor (EGF) in gland cells, which may contribute to its role in tumorigenesis. This compound induces apoptosis in human pathogens such as Helicobacter pylori, Chlamydia pneumoniae, and Candida albicans, but not in normal human cells.

Formula: C₁₃H₁₀Cl₄N₂O₄

Purity: Min. 95%

Molecular weight: 400.04 g/mol

Ref: 3D-DIA11563