Porcupine-IN-1 is a small molecule inhibitor that targets the Porcupine enzyme, which is involved in the Wnt signaling pathway, a crucial pathway for cell growth and differentiation. This compound is particularly significant in cancer research, as aberrations in Wnt signaling are associated with various malignancies. Porcupine-IN-1 is characterized by its ability to inhibit the palmitoylation of Wnt proteins, thereby preventing their secretion and subsequent activation of Wnt signaling. The compound is typically studied for its potential therapeutic applications in treating cancers that exhibit Wnt pathway dysregulation. In terms of its chemical properties, Porcupine-IN-1 is a synthetic organic compound, and its structure includes specific functional groups that contribute to its inhibitory activity. The compound's efficacy and safety profile are subjects of ongoing research, with studies focusing on its pharmacokinetics, bioavailability, and potential side effects in biological systems. Overall, Porcupine-IN-1 represents a promising avenue for targeted cancer therapies, particularly in tumors where Wnt signaling plays a pivotal role.

Porcupine-IN-1 is an inhibitor of the Wnt and hedgehog signaling pathways (IC
50
s = 0.5 and 71 nM, respectively, in cell-based reporter assays). It inhibits secretion of Wnt3A from Wnt3A-transfected HEK293T cells when used at a concentration of 0.1 μM, indicating inhibition of porcupine, an enzyme that catalyzes palmitoylation of Wnt proteins.

Porcupine-IN-1

2036044-77-4: Porcupine-IN-1 is a small molecule inhibitor that targets the Porcupine enzyme, which is involved in the Wnt signaling pathway, a crucial pathway for cell growth and differentiation. This compound is particularly significant in cancer research, as aberrations in Wnt signaling are associated with various malignancies. Porcupine-IN-1 is characterized by its ability to inhibit the palmitoylation of Wnt proteins, thereby preventing their secretion and subsequent activation of Wnt signaling. The compound is typically studied for its potential therapeutic applications in treating cancers that exhibit Wnt pathway dysregulation. In terms of its chemical properties, Porcupine-IN-1 is a synthetic organic compound, and its structure includes specific functional groups that contribute to its inhibitory activity. The compound's efficacy and safety profile are subjects of ongoing research, with studies focusing on its pharmacokinetics, bioavailability, and potential side effects in biological systems. Overall, Porcupine-IN-1 represents a promising avenue for targeted cancer therapies, particularly in tumors where Wnt signaling plays a pivotal role.

Porcupine-In-1

Porcn-IN-1

Porcn-IN-1 (Porcupine-IN-1) is an effective porcupine inhibitor (IC50: 0.5±0.2 nM).

CAS 2036044-77-4

Porcupine-IN-1

Porcupine-In-1

Ref: IN-DA01EO6G

Porcn-IN-1

Ref: 54-BUP05478

Porcn-IN-1

Ref: TM-T4438