Description:4-Azido-4-deoxy-D-glucose is a derivative of glucose where the hydroxyl group at the fourth carbon is replaced by an azido group (-N3). This modification imparts unique chemical properties, making it a valuable compound in biochemical research and applications. The azido group is known for its ability to participate in click chemistry, particularly in reactions such as azide-alkyne cycloaddition, which is useful for bioconjugation and labeling studies. The compound is typically a white to off-white solid and is soluble in polar solvents like water and dimethyl sulfoxide (DMSO). Its structure allows it to mimic glucose, enabling it to be utilized in various biological assays and studies involving glucose metabolism. However, due to the presence of the azido group, it may exhibit different biological activities compared to its parent compound, D-glucose. Safety precautions should be taken when handling this compound, as azides can be potentially hazardous. Overall, 4-azido-4-deoxy-D-glucose serves as an important tool in chemical biology and medicinal chemistry.
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