CAS 203911-27-7

Fasudil dihydrochloride

Description:

Fasudil dihydrochloride is a pharmacological compound primarily recognized for its role as a selective inhibitor of Rho kinase (ROCK), which is involved in various cellular processes, including smooth muscle contraction and cell migration. This compound is often utilized in research and clinical settings for its potential therapeutic effects in conditions such as cerebral vasospasm, ischemic stroke, and certain neurodegenerative diseases. Fasudil dihydrochloride is characterized by its solubility in water due to the presence of two hydrochloride groups, which enhance its bioavailability. The molecular structure includes a piperazine ring, contributing to its pharmacological activity. Its mechanism of action involves the modulation of signaling pathways that regulate vascular tone and neuronal function. As with many pharmacological agents, the safety profile, dosage, and potential side effects are critical considerations in its application, necessitating thorough clinical evaluation. Overall, Fasudil dihydrochloride represents a significant compound in the field of medicinal chemistry, with ongoing research into its broader therapeutic implications.

Formula: C₁₄H₁₇N₃O₂SHCl

Synonyms:

• HA-1077, Dihydrochloride Salt
• Fasudil dihydrochloride hydrate
• 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride

Fasudil dihydrochloride, 99+%

CAS: 203911-27-7

Fasudil dihydrochloride is used in the inhibition of contractile responses to potassium chloride, phenylephnne (PHE), prostaglandin and hepatic stellate cells spreading. It is also used in the formation of stress fibers and in medicine. This Thermo Scientific Chemicals brand product was originally

Formula: C₁₄H₁₉Cl₂N₃O₂S

Purity: 99+%

Molecular weight: 364.29

Ref: 02-J60594

Isoquinoline, 5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]-, hydrochloride (1:2)

CAS: 203911-27-7

Formula: C₁₄H₁₇N₃O₂S

Purity: %

Color and Shape: Solid

Molecular weight: 291.3687

Ref: IN-DA002973

HA-1077 dihydrochloride

CAS: 203911-27-7

Formula: C₁₄H₁₇N₃O₂S₂HCl

Molecular weight: 364.29

Ref: 7W-GK0206

HA-1077 Dihydrochloride Salt

CAS: 203911-27-7

HA-1077 Dihydrochloride Salt

Formula: C₁₄H₁₇N₃O₂S·2ClH

Purity: >99%

Color and Shape: white to off-white crystalline solid

Molecular weight: 364.29g/mol

Ref: 54-BIH1037

Fasudil dihydrochloride

CAS: 203911-27-7

Fasudil dihydrochloride (HA-1077/AT877) is a RhoA/ROCK inhibitor with kinase-blocking properties and acts as a vasodilator.

Formula: C₁₄H₁₉Cl₂N₃O₂S

Color and Shape: Solid

Molecular weight: 364.29

Ref: TM-T61382

1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride

Controlled Product

CAS: 203911-27-7

Applications A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).
References Hidaka, H., et al.: Acta Nurochir. (Wien), 90 (1988) Sward., K., el a.: J. Physiol., 522, 33 (2000),

Formula: C₁₄H₁₇N₃O₂S·2HCl

Color and Shape: Neat

Molecular weight: 364.29056

Ref: TR-I882200