CAS 204205-90-3

Indibulin

Description:

Indibulin, with the CAS number 204205-90-3, is a synthetic compound that functions primarily as an antitumor agent. It belongs to a class of drugs known as microtubule inhibitors, which disrupt the normal function of microtubules, essential components of the cell's cytoskeleton. By interfering with microtubule dynamics, Indibulin inhibits cell division, leading to apoptosis in rapidly dividing cancer cells. The compound has shown potential in treating various types of cancer, including solid tumors. Indibulin is characterized by its specific molecular structure, which contributes to its biological activity and pharmacological properties. It is typically administered in a clinical setting, and its efficacy and safety profile are evaluated through clinical trials. As with many antineoplastic agents, potential side effects may include myelosuppression, gastrointestinal disturbances, and peripheral neuropathy. Ongoing research continues to explore its mechanisms of action and potential combinations with other therapeutic agents to enhance its anticancer effects.

Formula: C₂₂H₁₆ClN₃O₂

InChI: InChI=1/C22H16ClN3O2/c23-16-7-5-15(6-8-16)13-26-14-19(18-3-1-2-4-20(18)26)21(27)22(28)25-17-9-11-24-12-10-17/h1-12,14H,13H2,(H,24,25,28)

SMILES: c1ccc2c(c1)c(cn2Cc1ccc(cc1)Cl)C(=O)C(=O)N=c1cc[nH]cc1

Synonyms:

• 2-(1-(4-Chlorophenylmethyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide
• 2-[1-(4-chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-(pyridin-4-yl)acetamide

Indibulin

CAS: 204205-90-3

Indibulin (D 24851), a synthetic molecule, inhibits tubulin assembly, has anticancer properties, and is neurotoxicity-minimal.

Formula: C₂₂H₁₆ClN₃O₂

Purity: 99.36%

Color and Shape: Solid

Molecular weight: 389.83

Ref: TM-T15576

1H-Indole-3-acetamide, 1-[(4-chlorophenyl)methyl]-α-oxo-N-4-pyridinyl-

CAS: 204205-90-3

Formula: C₂₂H₁₆ClN₃O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 389.8343

Ref: IN-DA0029CB

2-(1-(4-Chlorobenzyl)-1H-indol-3-yl)-2-oxo-N-(pyridin-4-yl)acetamide

CAS: 204205-90-3

Formula: C₂₂H₁₆ClN₃O₂

Purity: 98%

Molecular weight: 389.84

Ref: 10-F325477

Indibulin

Controlled Product

CAS: 204205-90-3

Indibulin is a potent antitumor agent that inhibits the assembly of tubulin. It has been shown to have significant cytotoxicity against prostate cancer cells and potent antiangiogenic properties. Indibulin has been shown to inhibit the production of epidermal growth factor, which is involved in tumor angiogenesis, by binding to the epidermal growth factor receptor. Indibulin also binds to excipients, such as mannitol and lactose, forming a granulate for intravenous injection. This drug has been shown to have pharmacokinetic properties in vitro and in vivo studies.

Formula: C₂₂H₁₆ClN₃O₂

Purity: Min. 95%

Molecular weight: 389.83 g/mol

Ref: 3D-EIA20590