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CAS 204251-24-1

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Fmoc-L-Glutamic acid-O-tert-butyl ester hydrate

Description:
Fmoc-L-Glutamic acid-O-tert-butyl ester hydrate is a derivative of glutamic acid, characterized by the presence of a fluorenylmethyloxycarbonyl (Fmoc) protective group and a tert-butyl ester. This compound is typically used in peptide synthesis, particularly in solid-phase peptide synthesis, due to its ability to protect the amino group of glutamic acid while allowing for further functionalization. The Fmoc group is known for its stability under basic conditions and can be removed under mild acidic conditions, facilitating the sequential addition of amino acids. The tert-butyl ester provides additional protection for the carboxylic acid group, enhancing the compound's stability and solubility in organic solvents. As a hydrate, it contains water molecules, which can influence its solubility and crystallization properties. Overall, Fmoc-L-Glutamic acid-O-tert-butyl ester hydrate is a valuable intermediate in the synthesis of peptides and other bioactive compounds, contributing to the field of medicinal chemistry and biochemistry.
Formula:C24H26NO6
InChI:InChI=1/C24H27NO6/c1-24(2,3)31-21(26)13-12-20(22(27)28)25-23(29)30-14-19-17-10-6-4-8-15(17)16-9-5-7-11-18(16)19/h4-11,19-20H,12-14H2,1-3H3,(H,25,29)(H,27,28)/p-1/t20-/m0/s1
SMILES:CC(C)(C)OC(=O)CC[C@@H](C(=O)[O-])N=C(O)OCC1c2ccccc2c2ccccc12
Synonyms:
  • N-Fmoc-L-glutamic acid gamma-tert-butyl ester monohydrate
  • N-(9-Fluorenylmethoxycarbonyl)-L-glutamic acid-O-tert-butyl ester monohydrate
  • (2S)-5-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoic acid hydrate (non-preferred name)
  • (2S)-5-tert-butoxy-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-5-oxopentanoate
  • Fmoc-L-Glu(OtBu)-OH Hydrate
  • Fmoc-Glu(OtBu)-OH・H2O
  • Fmoc-Glu(tBu)-OH・H2O
  • Fmoc-Glu(Otbu)-Oh H2O
  • Fmoc-L-Glutamic  Acid  O-Tert-Butyl  Ester  Monohydrate
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