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CAS 204260-38-8

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Fmoc-4-methyl-D-phenylalanine

Description:
Fmoc-4-methyl-D-phenylalanine is a derivative of the amino acid phenylalanine, characterized by the presence of a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a methyl group at the para position of the phenyl ring. This compound is commonly used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), due to the stability of the Fmoc group under basic conditions, which allows for selective deprotection. The presence of the D-enantiomer of phenylalanine introduces chirality, which can be crucial for the biological activity of peptides. Fmoc-4-methyl-D-phenylalanine exhibits hydrophobic characteristics due to the aromatic methyl group, influencing the overall properties of peptides it is incorporated into, such as solubility and folding. Additionally, its molecular structure contributes to the steric and electronic properties of the resulting peptides, making it a valuable building block in the design of bioactive compounds and pharmaceuticals. The compound is typically handled under standard laboratory conditions, with appropriate safety measures due to its chemical nature.
Formula:C25H23NO4
Synonyms:
  • Fmoc-D-4-Methylphenylalanine
  • Fmoc-D-4-Methylphe
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