CAS 20449-79-0

Melittin

Description:

Melittin is a peptide derived from the venom of honeybees (Apis mellifera) and is known for its potent biological activity. It consists of 26 amino acids and has a molecular weight of approximately 2846 Da. Melittin is characterized by its amphipathic nature, which allows it to interact with lipid membranes, leading to membrane disruption and cell lysis. This property makes it a subject of interest in various fields, including immunology and cancer research, as it exhibits antimicrobial and anti-cancer activities. Additionally, melittin can induce inflammation and has been studied for its potential therapeutic applications, although its cytotoxic effects necessitate careful consideration in medical use. The peptide is soluble in water and exhibits a helical structure in membrane environments, contributing to its ability to form pores in lipid bilayers. Overall, melittin serves as a valuable model for understanding peptide-membrane interactions and holds promise for developing novel therapeutic agents.

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

InChI: InChI=1/C131H229N39O31/c1-23-71(16)102(163-97(176)60-135)122(194)146-62-98(177)148-74(19)109(181)164-100(69(12)13)124(196)160-88(55-65(4)5)116(188)155-84(41-30-33-51-134)115(187)165-101(70(14)15)125(197)161-90(57-67(8)9)118(190)168-106(77(22)173)128(200)169-105(76(21)172)123(195)147-63-99(178)150-92(58-68(10)11)129(201)170-54-36-44-94(170)121(193)149-75(20)108(180)158-89(56-66(6)7)117(189)166-104(73(18)25-3)127(199)162-93(64-171)120(192)159-91(59-78-61-145-80-38-27-26-37-79(78)80)119(191)167-103(72(17)24-2)126(198)157-83(40-29-32-50-133)111(183)154-85(42-34-52-143-130(139)140)112(184)152-82(39-28-31-49-132)110(182)153-86(43-35-53-144-131(141)142)113(185)156-87(46-48-96(137)175)114(186)151-81(107(138)179)45-47-95(136)174/h26-27,37-38,61,65-77,81-94,100-106,145,171-173H,23-25,28-36,39-60,62-64,132-135H2,1-22H3,(H2,136,174)(H2,137,175)(H2,138,179)(H,146,194)(H,147,195)(H,148,177)(H,149,193)(H,150,178)(H,151,186)(H,152,184)(H,153,182)(H,154,183)(H,155,188)(H,156,185)(H,157,198)(H,158,180)(H,159,192)(H,160,196)(H,161,197)(H,162,199)(H,163,176)(H,164,181)(H,165,187)(H,166,189)(H,167,191)(H,168,190)(H,169,200)(H4,139,140,143)(H4,141,142,144)/t71-,72-,73-,74-,75-,76+,77+,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,100-,101-,102-,103-,104-,105-,106-/m0/s1

Synonyms:

• H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2
• Melittin From Bee Venom Sequencing*Grade
• Beevenommelittin

Melittin

CAS: 20449-79-0

Synthetic melittin, the main component of the honeybee venom. The amphiphilic nature of this antimicrobial peptide makes it a excellent model compound for monitoring lipid-protein interactions in membranes. Adade et al. observed that melittin peptide could kill Trypanosoma cruzi parasites by inducing different cell death pathways.

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

Purity: 98.5%

Color and Shape: White

Molecular weight: 2846.5

Ref: 01-4030808

Melittin

CAS: 20449-79-0

Melittin

Purity: 98%

Molecular weight: 2,846.46g/mol

Ref: 54-BIM0170

Melittin

CAS: 20449-79-0

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

Purity: ≥ 97.0%

Color and Shape: White to faint yellow or faint tan powder

Molecular weight: 2846.46

Ref: 7W-GK3910

Melittin

CAS: 20449-79-0

Melittin: principal bee venom toxin, 26 amino acids, activates low-weight PLA2, not high-weight PLA2.

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

Purity: 98.37% - 99.92%

Color and Shape: Solid

Molecular weight: 2846.46

Ref: TM-TP1299

Melittin - 95%

CAS: 20449-79-0

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have antitumoral effects in various cancers. For example, honey bee venom (XM176021) was shown to reduce metastases of breast cancer to the lungs and inhibit tumour growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin (FM10065), showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 2,846.47 g/mol

Ref: 3D-FM10065

Melittin

CAS: 20449-79-0

Melittin is a 26-residue peptide originally isolated from venom of the European honeybee. Melittin is a cationic, hemolytic peptide from honey bee venom. Melittin lowers the surface tension at the plasma membrane and causes cell lysis. Melittin exhibits potent anti-inflammatory and antimicrobial activity. Melittin has been extensively used as a model peptide for observing membrane lipid-protein interactions.

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

Color and Shape: Powder

Molecular weight: 2,846.47 g/mol

Ref: 3D-CRB1000015

Melittin, 70%

CAS: 20449-79-0

Apitherapy (the use of honey bee products in alternative medicine) is an emerging field, with a long history of unsupported health benefits, particularly in cancer. Components of bee venom have been demonstrated to have antitumoral effects in various cancers. For example, honey bee venom (XM176021) was shown to reduce metastases of breast cancer to the lungs and inhibit tumour growth (Orsolić, et al., 2003). Similarly, the active component of bee venom, a peptide called melittin (FM10065), showed anticancer selectivity through undefined molecular mechanisms and suggests novel treatment strategies for aggressive breast cancers (Duffy, et al., 2020).

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 2,846.46 g/mol

Ref: 3D-XM176021

Melittin

CAS: 20449-79-0

Melittin is a major component of bee venom that has been shown to have antibacterial efficacy against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. It also demonstrates anti-viral activity, for example it inhibits human immunodeficiency virus and herpes simplex virus. Furthermore it can be used in the treatment of inflammatory-related illnesses due to it inhibiting the phospholipase A2 enzyme. In addition to this Melittin's abaility to inhibit inflammatory mediators such as nitric oxide and cyclooxygenase-2 aids in the treatment of inflammatory diseases. As a result of Melittin having the capabilities of attacking lipid membranes and it surpressing COX-2 mRNA expression it can also be used in the treatment of tumours. The bound form of melittin is not toxic to mammalian cells, but it is toxic when it is released into the cell cytoplasm. Melittin has been shown to inhibit transcriptional regulation and locomotor activity in mice. This may be due to its ability to bind DNA, preventing transcription and translation of certain genes. Lastly It has strong hemolytic activity and been seen to increase insulin secretion via depolarization of pancreatic beta-cells. Melittin is a diverse peptide which can be used ina whole spectrum of research and therapeutic areas.

Formula: C₁₃₁H₂₂₉N₃₉O₃₁

Purity: Min. 95%

Molecular weight: 2,846.47 g/mol

Ref: 3D-TOX-70001-PI