CAS 204519-65-3

Gemifloxacin mesylate

Description:

Gemifloxacin mesylate is a synthetic fluoroquinolone antibiotic, primarily used to treat respiratory tract infections. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication and repair. The substance is characterized by its high oral bioavailability and favorable pharmacokinetic profile, allowing for once-daily dosing. Gemifloxacin mesylate is typically administered in the form of its mesylate salt, which enhances its solubility and stability. The compound is known for its low potential for drug interactions and a relatively favorable safety profile, although it may cause side effects such as gastrointestinal disturbances and, in rare cases, tendonitis or tendon rupture. Its chemical structure includes a bicyclic core with a fluorine atom, contributing to its potency and spectrum of activity. As with all antibiotics, appropriate use is crucial to minimize the risk of developing antibiotic resistance.

Formula: C₁₈H₂₀FN₅O₄·CH₄O₃S

InChI: InChI=1/C18H20FN5O4.CH4O3S/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17;1-5(2,3)4/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27);1H3,(H,2,3,4)/b22-14+;

InChI key: InChIKey=JIYMVSQRGZEYAX-CWUUNJJBNA-N

SMILES: O=C1C=2C(N(C=C1C(O)=O)C3CC3)=NC(=C(F)C2)N4C/C(=N\OC)/C(CN)C4.S(C)(=O)(=O)O

Synonyms:

• (Z)-7-[3-(Aminomethyl)-4-(methoxyamino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acid Methanesulfonate
• 1,8-Naphthyridine-3-Carboxylic Acid, 7-[3-(Aminomethyl)-4-(Methoxyamino)-1-Pyrrolidinyl]-1-Cyclopropyl-6-Fluoro-1,4-Dihydro-4-Oxo-, Methanesulfonate (1:1)
• 1,8-Naphthyridine-3-carboxylic acid, 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate
• 204519-65-3
• 7-[(4Z)-3-(aminomethyl)-4-(methoxyimino)pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid methanesulfonate (1:1)
• 7-[3-(Aminomethyl)-4-(Methoxyamino)Pyrrolidin-1-Yl]-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphthyridine-3-Carboxylic Acid Methanesulfonate
• Acide 7-[3-(Aminométhyl)-4-(Méthoxyamino)Pyrrolidin-1-Yl]-1-Cyclopropyl-6-Fluoro-4-Oxo-1,4-Dihydro-1,8-Naphtyridine-3-Carboxylique - Acide Méthanesulfonique (1:1)
• Factive
• Floxguard
• Gemifloxacin mesylate
• Gemixa
• LB 20304a
• Sb 265805-S

Gemifloxacin mesylate

CAS: 204519-65-3

Inhibits DNA gyrase and topoisomerase IV

Formula: C₁₉H₂₄FN₅O₇S

Purity: Min. 95%

Color and Shape: White Beige Powder

Molecular weight: 485.49 g/mol

Ref: 3D-AG32179