CAS 20535-83-5

O6-Methylguanine

Description:

O6-Methylguanine is a modified nucleobase that is a derivative of guanine, one of the four primary bases in DNA. It is characterized by the addition of a methyl group at the oxygen atom in the 6-position of the guanine structure. This modification can disrupt normal base pairing during DNA replication, leading to potential mutations. O6-Methylguanine is known to pair with thymine instead of cytosine, which can result in G:C to A:T transitions in the genetic code. This compound is often studied in the context of DNA damage and repair mechanisms, as it is a common product of alkylating agents, which are used in certain chemotherapeutic treatments. The presence of O6-Methylguanine in DNA is associated with various forms of cancer, making it a significant focus in cancer research and toxicology. Its CAS number, 20535-83-5, is used for identification in chemical databases and regulatory contexts. Overall, O6-Methylguanine serves as an important biomarker for understanding the effects of environmental and chemical exposures on genetic integrity.

Formula: C₆H₇N₅O

InChI: InChI=1S/C6H7N5O/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)

InChI key: InChIKey=BXJHWYVXLGLDMZ-UHFFFAOYSA-N

SMILES: O(C)C1=C2C(=NC(N)=N1)N=CN2

Synonyms:

• 1H-Purin-2-amine, 6-methoxy-
• 2-Amino-6-methoxypurine
• 6-Methoxy-9H-purin-2-amine
• 6-Methoxyguanine
• 6-O-Methylguanine
• 6-methoxy-5H-purin-2-amine
• 6-methoxy-7H-purin-2-amine
• 9H-Purin-2-amine, 6-methoxy-
• Aminomethoxypurine,97%
• NSC 37364
• O⁶-Methylguanine

6-O-Methylguanine

CAS: 20535-83-5

Formula: C₆H₇N₅O

Purity: >97.0%(T)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 165.16

Ref: 3B-A1151

6-Methoxy-7h-purin-2-amine

CAS: 20535-83-5

Formula: C₆H₇N₅O

Purity: 97%

Color and Shape: Solid

Molecular weight: 165.1527

Ref: IN-DA002A1B

6-O-Methylguanine

CAS: 20535-83-5

Formula: C₆H₇N₅O

Molecular weight: 165.15

Ref: 7W-GK9494

Nelarabine Impurity 11

CAS: 20535-83-5

Formula: C₆H₇N₅O

Color and Shape: Off-White Solid

Molecular weight: 165.16

Ref: 4Z-N-525

2-Amino-6-methoxy-9H-purine

CAS: 20535-83-5

2-Amino-6-methoxy-9H-purine

Formula: C₆H₇N₅O

Purity: 98%

Color and Shape: off-white solid

Molecular weight: 165.15g/mol

Ref: 54-OR3726

6-O-Methylguanine

Controlled Product

CAS: 20535-83-5

Formula: C₆H₇N₅O

Color and Shape: Off-White

Molecular weight: 165.15

Ref: TR-M311800

2-Amino-6-methoxypurine

CAS: 20535-83-5

Intermediate in the synthesis of nelarabine

Formula: C₆H₇N₅O

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 165.15 g/mol

Ref: 3D-FA08200

6-Methoxy-9H-purin-2-amine

CAS: 20535-83-5

Formula: C₆H₇N₅O

Purity: 97%

Color and Shape: Solid, No data available.

Molecular weight: 165.156

Ref: 10-F065033

6-O-Methylguanine

CAS: 20535-83-5

Formula: C₆H₇N₅O

Molecular weight: 165.16

Ref: ST-EA-CP-N38004