CAS 20537-88-6

Amifostine

Description:

Amifostine, with the CAS number 20537-88-6, is a cytoprotective agent primarily used to reduce the side effects of chemotherapy and radiation therapy. It is a phosphorylated derivative of the naturally occurring amino acid cysteine and acts as a free radical scavenger, thereby protecting normal tissues from oxidative damage. Amifostine is known for its ability to mitigate nephrotoxicity associated with certain chemotherapeutic agents, particularly cisplatin, and to reduce xerostomia (dry mouth) in patients undergoing head and neck radiation. The compound is administered intravenously or subcutaneously and is characterized by its rapid metabolism to its active form, which enhances its protective effects. Its chemical structure includes a thiol group, which is crucial for its antioxidant properties. While generally well-tolerated, amifostine can cause side effects such as hypotension, nausea, and vomiting. Its use is often tailored to individual patient needs, balancing the benefits of cytoprotection against potential adverse effects.

Formula: C₅H₁₅N₂O₃PS

InChI: InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10)

InChI key: InChIKey=JKOQGQFVAUAYPM-UHFFFAOYSA-N

SMILES: S(CCNCCCN)P(=O)(O)O

Synonyms:

• ([2-[(3-Aminopropyl)amino]ethyl]sulfanyl)phosphonic acid
• 2-(3-Aminopropyl)aminoethyl phosphorothioate
• 2-(3-Aminopropylamino)ethyl thiophosphate
• Amifostin
• Aminopropyl Aminoethylthiophosphate
• Aminopropylaminoethyl thiophosphate
• Ethanethiol, 2-[(3-aminopropyl)amino]-, 1-(dihydrogen phosphate)
• Ethanethiol, 2-[(3-aminopropyl)amino]-, dihydrogen phosphate (ester)
• Ethiofos
• Ethyol
• Gammaphos
• NSC 296961
• Phosphorothioic acid S-(2-((3-aminopropyl)amino)ethyl) ester
• S 8744
• S-2-(3-Aminopropylamino)Ethyl O,O-Dihydrogen Phosphorothioate
• S-[2-(3-Aminopropylamino)ethyl] phosphorothioate
• S-[2-[(3-Aminopropyl)amino]ethyl] dihydrogen phosphorothioate
• S-[N-(3-Aminopropyl)-2-aminoethyl] dihydrogen thiophosphate
• Sapep
• Wr 2721
• Wr 2721C
• Wr2721

Ethanethiol, 2-[(3-aminopropyl)amino]-, 1-(dihydrogen phosphate)

CAS: 20537-88-6

Formula: C₅H₁₅N₂O₃PS

Purity: 98%

Color and Shape: Solid

Molecular weight: 214.2230

Ref: IN-DA002A12

Amifostine

CAS: 20537-88-6

Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.

Formula: C₅H₁₅N₂O₃PS

Purity: 99.59%

Color and Shape: White Solid

Molecular weight: 214.22

Ref: TM-T3289

Amifostine

CAS: 20537-88-6

Formula: C₅H₁₅N₂O₃PS

Color and Shape: White To Off-White Solid

Molecular weight: 214.22

Ref: 4Z-A-256001

Amifostine

CAS: 20537-88-6

Amifostine

Purity: ≥98%

Molecular weight: 214.22g/mol

Ref: 54-BUP10756

AMIFOSTINE

CAS: 20537-88-6

Purity: 97.0%

Molecular weight: 214.22000122070312

Ref: 10-F387722

Amifostine

CAS: 20537-88-6

Radio- and chemoprotective agent

Formula: C₅H₁₅N₂O₃PS

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 214.22 g/mol

Ref: 3D-FA17353

Amifostine

CAS: 20537-88-6

Formula: C₅H₁₅N₂O₃PS

Molecular weight: 214.22

Ref: ST-EA-CP-A295000