Propargyl-PEG8-acid is a chemical compound characterized by its structure, which includes a propargyl group and a polyethylene glycol (PEG) moiety with eight ethylene glycol units, terminated by a carboxylic acid functional group. This compound is typically used in bioconjugation and drug delivery applications due to its hydrophilic PEG segment, which enhances solubility and biocompatibility. The propargyl group allows for click chemistry reactions, particularly with azides, facilitating the attachment of various biomolecules or therapeutic agents. The presence of the carboxylic acid group provides a site for further functionalization or conjugation, making it versatile in synthetic chemistry. Additionally, the PEG portion contributes to reduced protein adsorption and improved circulation time in biological systems. Overall, Propargyl-PEG8-acid is valued in research and pharmaceutical development for its functional properties and ability to form stable conjugates with a variety of molecules.

Propargyl-PEG8-acid has an alkyne group and an acid group. The acid group can derivatize amine-containing molecules in the presence of activators such as EDC or HATU. The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The PEG units help increase the solubility of the molecule in aqueous environment.

Propargyl-PEG8-acid

2055014-94-1: Propargyl-PEG8-acid is a chemical compound characterized by its structure, which includes a propargyl group and a polyethylene glycol (PEG) moiety with eight ethylene glycol units, terminated by a carboxylic acid functional group. This compound is typically used in bioconjugation and drug delivery applications due to its hydrophilic PEG segment, which enhances solubility and biocompatibility. The propargyl group allows for click chemistry reactions, particularly with azides, facilitating the attachment of various biomolecules or therapeutic agents. The presence of the carboxylic acid group provides a site for further functionalization or conjugation, making it versatile in synthetic chemistry. Additionally, the PEG portion contributes to reduced protein adsorption and improved circulation time in biological systems. Overall, Propargyl-PEG8-acid is valued in research and pharmaceutical development for its functional properties and ability to form stable conjugates with a variety of molecules.

Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria[1].

CAS 2055014-94-1

Propargyl-PEG8-acid

Propargyl-PEG8-acid

Ref: IN-DA019E1Z

Propargyl-PEG8-acid

Ref: 54-BIPG1709

Propargyl-PEG8-acid

Ref: 10-F987003

Propargyl-PEG8-acid

Ref: TM-T16648