Acid-PEG6-SS-PEG6-Acid, identified by the CAS number 2055014-97-4, is a bifunctional polyethylene glycol (PEG) derivative characterized by its unique structure that includes two acid functional groups and a disulfide linkage. The PEG segments provide hydrophilicity, enhancing solubility in aqueous environments, while the acid groups can facilitate conjugation with various biomolecules or drugs, making it useful in drug delivery applications. The disulfide bond is particularly significant as it can be cleaved under reducing conditions, allowing for controlled release of the attached therapeutic agents in biological systems. This compound is often utilized in the development of polymeric micelles, nanoparticles, or hydrogels for targeted therapy, particularly in cancer treatment. Its biocompatibility and ability to modulate release profiles make it a valuable component in the field of biomedical engineering and pharmaceutical formulations. Overall, Acid-PEG6-SS-PEG6-Acid exemplifies the versatility of PEG-based materials in enhancing the efficacy and safety of therapeutic interventions.

Acid-PEG6-SS-PEG6-acid is a homobifunctional cleavable linker.  The terminal carboxylic acids can react with primary amines in the presences of activators such as EDC and HATU to form stable amide bonds. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. PEG6 spacer increase the compound;s solubility.

Acid-PEG6-SS-PEG6-Acid

2055014-97-4: Acid-PEG6-SS-PEG6-Acid, identified by the CAS number 2055014-97-4, is a bifunctional polyethylene glycol (PEG) derivative characterized by its unique structure that includes two acid functional groups and a disulfide linkage. The PEG segments provide hydrophilicity, enhancing solubility in aqueous environments, while the acid groups can facilitate conjugation with various biomolecules or drugs, making it useful in drug delivery applications. The disulfide bond is particularly significant as it can be cleaved under reducing conditions, allowing for controlled release of the attached therapeutic agents in biological systems. This compound is often utilized in the development of polymeric micelles, nanoparticles, or hydrogels for targeted therapy, particularly in cancer treatment. Its biocompatibility and ability to modulate release profiles make it a valuable component in the field of biomedical engineering and pharmaceutical formulations. Overall, Acid-PEG6-SS-PEG6-Acid exemplifies the versatility of PEG-based materials in enhancing the efficacy and safety of therapeutic interventions.

<p>Bis-(PEG6-acid)-SS: a cleavable, 6-unit PEG linker for antibody-drug conjugate synthesis.</p>

CAS 2055014-97-4

Acid-PEG6-SS-PEG6-Acid

Bis-(PEG6-acid)-SS

Ref: TM-T17630