CAS 2055024-59-2

L-Ornithinamide, N-[13-(9H-fluoren-9-yl)-1,11-dioxo-4,7,12-trioxa-10-azatridec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

Description:

L-Ornithinamide, N-[13-(9H-fluoren-9-yl)-1,11-dioxo-4,7,12-trioxa-10-azatridec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- is a complex organic compound characterized by its unique structural features, including multiple functional groups and a fluorene moiety. This compound is likely to exhibit properties typical of amides, such as potential solubility in polar solvents and the ability to participate in hydrogen bonding due to the presence of amine and hydroxyl groups. The presence of the fluorene structure may impart specific electronic properties, influencing its reactivity and interaction with biological systems. Additionally, the compound's design suggests potential applications in medicinal chemistry, particularly in drug development, where its structural complexity could be leveraged for targeting specific biological pathways. Its molecular weight, stability, and reactivity would depend on the specific arrangement of its functional groups and the overall three-dimensional conformation. Further studies would be necessary to elucidate its full chemical behavior and potential applications.

Formula: C₄₀H₅₂N₆O₉

Synonyms:

• FmocNH-PEG2-C2-Val-Cit-PAB-OH
• Fmoc-PEG2-Val-Cit-PAB-OH
• L-Ornithinamide, N-[13-(9H-fluoren-9-yl)-1,11-dioxo-4,7,12-trioxa-10-azatridec-1-yl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

Fmoc-PEG2-Val-Cit-PAB-OH

CAS: 2055024-59-2

Fmoc-PEG2-Val-Cit-PAB-OH is a cleavable ADC linker that features a Boc-protected amine, hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzyl alcohol on the PAB can be used for conjugating reactive groups (e.g., PNP) to attach a payload. The Fmoc protecting group is removable with piperidine, revealing a primary amine for amide bond formation in conjugation reactions. The Val-Cit-PAB segment is cleaved by cellular proteases to efficiently release the payload inside cells.

Formula: C₄₀H₅₂N₆O₉

Color and Shape: Solid

Molecular weight: 760.876

Ref: TM-TYD-01945