CAS 2055024-61-6

L-Ornithinamide, N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

Description:

L-Ornithinamide, N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- is a complex organic compound characterized by its intricate structure, which includes multiple functional groups such as amides, hydroxymethyl, and carbonyl moieties. This compound is likely to exhibit properties typical of peptides and amino acid derivatives, including potential solubility in polar solvents due to the presence of hydroxyl and amine groups. Its molecular structure suggests it may participate in various biochemical interactions, making it of interest in pharmaceutical and biochemical research. The presence of multiple oxo and oxapentadecane units indicates a potential for unique reactivity and stability under specific conditions. Additionally, the compound's specific stereochemistry, particularly the L-configuration of the amino acids, may influence its biological activity and interactions with enzymes or receptors. Overall, this compound represents a fascinating area of study within medicinal chemistry and biochemistry, with potential applications in drug development and therapeutic interventions.

Formula: C₂₉H₅₀N₆O₉

Synonyms:

• L-Ornithinamide, N-(15-amino-1-oxo-4,7,10,13-tetraoxapentadec-1-yl)-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-
• NH2-PEG4-Val-Cit-PAB-OH

NH2-PEG4-Val-Cit-PAB-OH

CAS: 2055024-61-6

NH2-PEG4-Val-Cit-PAB-OH is a cleavable ADC linker that features a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on the PAB component is suitable for attaching reactive groups (such as PNP) to facilitate binding with drug payloads. The primary amine is versatile for reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, or other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular cathepsins, allowing efficient payload delivery via an elimination mechanism through the PAB structure.

Formula: C₂₉H₅₀N₆O₉

Color and Shape: Solid

Molecular weight: 626.742

Ref: TM-TYD-02059