CAS 2055024-62-7

L-Ornithinamide, N-[3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

Description:

L-Ornithinamide, N-[3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]- is a complex organic compound characterized by its multi-functional structure, which includes amino acid components and various functional groups. This substance features an ornithine derivative, indicating its potential role in biological processes, particularly in protein synthesis and metabolic pathways. The presence of multiple ethoxy groups suggests enhanced solubility and potential interactions with biological membranes. Additionally, the compound contains a hydroxymethylphenyl moiety, which may contribute to its reactivity and ability to form hydrogen bonds, influencing its biological activity. The amide linkages present in the structure indicate that it may exhibit properties typical of peptides, such as stability under physiological conditions. Overall, this compound's intricate structure implies potential applications in medicinal chemistry, particularly in drug design and development, where its unique characteristics could be leveraged for therapeutic purposes.

Formula: C₂₇H₄₆N₆O₈

Synonyms:

• NH2-PEG3-Val-Cit-PAB-OH
• L-Ornithinamide, N-[3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-1-oxopropyl]-L-valyl-N5-(aminocarbonyl)-N-[4-(hydroxymethyl)phenyl]-

NH2-PEG3-Val-Cit-PAB-OH

CAS: 2055024-62-7

NH2-PEG3-Val-Cit-PAB-OH is a cleavable ADC (antibody-drug conjugate) linker characterized by a primary amine, a hydrophilic PEG spacer, a Val-Cit dipeptide, and a PAB group. The benzyl alcohol on PAB facilitates conjugation with reactive groups like PNP, enabling attachment to drug payloads. The primary amine readily participates in various reactions such as coupling with carboxylic acids, reductive amination with ketones or aldehydes, and other specialized applications like SNAr reactions or heterocyclic chemistry. The Val-Cit dipeptide is cleaved by intracellular proteases, allowing efficient payload delivery through an elimination mechanism within the PAB structure.

Formula: C₂₇H₄₆N₆O₈

Color and Shape: Solid

Molecular weight: 582.69

Ref: TM-TYD-01972