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CAS 205526-22-3

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Fmoc-2-chloro-D-phenylalanine

Description:
Fmoc-2-chloro-D-phenylalanine is a derivative of the amino acid phenylalanine, modified with a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group and a chlorine substituent at the 2-position of the aromatic ring. This compound is typically used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS), where the Fmoc group serves as a protective group for the amino functionality, allowing for selective deprotection and coupling reactions. The presence of the chlorine atom can influence the reactivity and steric properties of the molecule, potentially affecting the overall synthesis and properties of the resulting peptides. Fmoc-2-chloro-D-phenylalanine is characterized by its stability under basic conditions, ease of handling, and compatibility with various coupling reagents. Additionally, it is important to note that the D-configuration of the amino acid can impart specific stereochemical properties that may be relevant in biological contexts. As with any chemical substance, proper safety measures should be observed when handling this compound in a laboratory setting.
Formula:C24H20ClNO4
Synonyms:
  • Fmoc-D-2-Chlorophenylalanine
  • Fmoc-D-2-Chlorophe
  • Fmoc-D-Phe(2-Cl)-OH
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