Orexin A, also known as hypocretin-1, is a neuropeptide that plays a crucial role in regulating arousal, wakefulness, and appetite. It is produced in the hypothalamus and is involved in various physiological processes, including the modulation of energy balance and the sleep-wake cycle. Orexin A is characterized by its structure as a 33-amino acid peptide, which includes a unique sequence that distinguishes it from other neuropeptides. The substance interacts with orexin receptors (OX1R and OX2R), influencing neurotransmitter release and promoting wakefulness. Its dysregulation has been linked to sleep disorders, particularly narcolepsy, where a deficiency in orexin signaling is observed. Orexin A is also being studied for its potential therapeutic applications in obesity and other metabolic disorders due to its role in appetite regulation. As a peptide, it is sensitive to degradation and typically requires specific conditions for stability in research and therapeutic contexts.

Orexin A

205599-75-3: Orexin A, also known as hypocretin-1, is a neuropeptide that plays a crucial role in regulating arousal, wakefulness, and appetite. It is produced in the hypothalamus and is involved in various physiological processes, including the modulation of energy balance and the sleep-wake cycle. Orexin A is characterized by its structure as a 33-amino acid peptide, which includes a unique sequence that distinguishes it from other neuropeptides. The substance interacts with orexin receptors (OX1R and OX2R), influencing neurotransmitter release and promoting wakefulness. Its dysregulation has been linked to sleep disorders, particularly narcolepsy, where a deficiency in orexin signaling is observed. Orexin A is also being studied for its potential therapeutic applications in obesity and other metabolic disorders due to its role in appetite regulation. As a peptide, it is sensitive to degradation and typically requires specific conditions for stability in research and therapeutic contexts.

<p>Orexin A is a neuropeptide that regulates the sleep-wake cycle and controls appetite. It has been shown to have a role in modulating the immune system, blood pressure, and energy metabolism. Orexin A is expressed in neurons and other cells in the brain, including astrocytes. It has been shown to regulate neuronal death by inhibiting pro-death signals such as caspase-3, which are released in response to stress or injury. Orexin A also interacts with toll-like receptors and receptor activity, which may be responsible for its effects on inflammatory responses.</p>

Orexin A human, rat, mouse

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CAS 205599-75-3

Orexin A

Orexin A human, rat, mouse

Ref: 3D-FIA59975

Orexin A trifluoroacetate

Ref: 3D-BO183537