CAS 2058-52-8

Clotiapine

Description:

Clotiapine is an antipsychotic medication primarily used in the treatment of schizophrenia and other psychotic disorders. It belongs to the class of thienobenzodiazepines, which are characterized by their unique chemical structure that includes a benzodiazepine ring fused to a thiophene ring. Clotiapine exhibits both antipsychotic and anxiolytic properties, making it effective in managing symptoms such as hallucinations, delusions, and anxiety. The substance acts primarily as a dopamine antagonist, influencing neurotransmitter activity in the brain, particularly dopamine and serotonin receptors. Clotiapine is known for its relatively favorable side effect profile compared to other antipsychotics, although it can still cause sedation, weight gain, and metabolic changes in some patients. Its pharmacokinetics involve oral administration, with metabolism occurring in the liver, leading to various metabolites. As with any medication, careful monitoring is essential to optimize therapeutic outcomes and minimize adverse effects.

Formula: C₁₈H₁₈ClN₃S

InChI: InChI=1S/C18H18ClN3S/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

InChI key: InChIKey=KAAZGXDPUNNEFN-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(=NC=3C(SC2=CC1)=CC=CC3)N4CCN(C)CC4

Synonyms:

• 2-Chloro-11-(4-Methylpiperazin-1-Yl)Dibenzo[B,F][1,4]Thiazepine
• 2-Chloro-11-(4-methyl-1-piperazinyl)dibenzo(b,f)(1,4)thiazepine
• 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)thiazepine
• Brn 0568276
• Clothiapin
• Clothiapine
• Clothiapine [USAN:BAN]
• Clotiapina
• Clotiapina [INN-Spanish]
• Clotiapinum
• Clotiapinum [INN-Latin]
• Deliton
• Dibenzo(b,f)(1,4)thiazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
• Dibenzothiazepine
• Entumin
• Entumine
• Etomine
• Etumine
• Hf 2159
• Lw 2159
• S-805C
• Unii-Z05Hcy0X1T
• W 130

13-chloro-10-(4-methylpiperazin-1-yl)-2-thia-9-azatricyclo[9.4.0.0,3,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaene

CAS: 2058-52-8

Formula: C₁₈H₁₈ClN₃S

Purity: 99%

Color and Shape: Solid

Molecular weight: 343.8736

Ref: IN-DA002ADN

Clothiapine

CAS: 2058-52-8

Clothiapine

Purity: ≥98%

Molecular weight: 343.87g/mol

Ref: 54-BUP21819

Clothiapine

CAS: 2058-52-8

Clothiapine is an atypical antipsychotic of the dibenzothiazepine chemical class.

Formula: C₁₈H₁₈ClN₃S

Purity: 99.93%

Color and Shape: Solid

Molecular weight: 343.87

Ref: TM-T23900

Clothiapine-d8

Controlled Product

CAS: 2058-52-8

Applications Clothiapine-d8, is the labeled analogue of Clothiapine (C588550), a atypical antipsychotic of the dibenzothiazepine chemical class. It has shown efficacy in treatment-resistant schizophrenic patients.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schmutz, J., et al.: Helvetica Chimica Acta 50, 245 (1967); Geller, V., et al.: Schizophrenia Research 80 (2-3), 343 (2005);

Formula: C₁₈H₁₀D₈ClN₃S

Color and Shape: Neat

Molecular weight: 351.92

Ref: TR-C588552

Clothiapine

Controlled Product

CAS: 2058-52-8

Stability Hygroscopic
Applications Clothiapine, is a atypical antipsychotic of the dibenzothiazepine chemical class. It has shown efficacy in treatment-resistant schizophrenic patients.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Schmutz, J., et al.: Helvetica Chimica Acta 50, 245 (1967); Geller, V., et al.: Schizophrenia Research 80 (2-3), 343 (2005);

Formula: C₁₈H₁₈ClN₃S

Color and Shape: Neat

Molecular weight: 343.87

Ref: TR-C588550

Clothiapine

Controlled Product

CAS: 2058-52-8

Clothiapine is a psychotropic agent, which is a type of drug used in psychiatry. It is sourced from the dibenzothiazepine class of compounds. As a thioxanthene derivative, clothiapine acts as a dopamine receptor antagonist, specifically targeting D2 receptors. This mode of action results in its antipsychotic effects by modulating neurotransmitter pathways in the brain, particularly those involving dopamine, which is often implicated in psychiatric disorders.

Formula: C₁₈H₁₈ClN₃S

Purity: Min. 95%

Molecular weight: 343.88 g/mol

Ref: 3D-FC178187