CAS 20594-83-6: Nalbuphine

Description: Nalbuphine is a synthetic opioid analgesic that is primarily used for the management of moderate to severe pain. It acts as a mixed agonist-antagonist, meaning it can activate certain opioid receptors while simultaneously blocking others, which can help reduce the risk of addiction and respiratory depression associated with traditional opioids. Chemically, nalbuphine is classified as a phenanthrene derivative and has a complex structure that includes a tertiary amine. It is typically administered via injection and has a relatively rapid onset of action. Nalbuphine is known for its ceiling effect, which limits its efficacy at higher doses, making it less likely to cause overdose compared to full agonists. Common side effects may include sedation, dizziness, and nausea, while its use is contraindicated in patients with respiratory depression or those who are hypersensitive to the drug. Nalbuphine is also utilized in certain anesthesia protocols and may be used in labor pain management due to its analgesic properties.

Formula: C₂₁H₂₇NO₄

InChI: InChI=1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6-11H2/t15-,16+,19-,20-,21+/m0/s1

InChI key: InChIKey=NETZHAKZCGBWSS-CEDHKZHLSA-N

SMILES: OC1=CC=C2C3=C1OC4C(O)CCC5(O)C(N(CCC345)CC6CCC6)C2

Synonyms:

• Morphinan-3,6α,14-triol, 17-(cyclobutylmethyl)-4,5α-epoxy-
• N-Cyclobutylmethyl-14-hydroxydihydronormorphine
• Nalbufina
• Nalbuphin
• Nalbuphine
• Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5α,6α)-
• MeSH ID: D009266
• (6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride
• Nalbuphine [INN:BAN]
• (5alpha,6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol
• Nalbufina [DCIT]
• N-Cyclobutylmethyl-4,5alpha-epoxy-3,6alpha,14-morphinantriol
• Morphinan-3,6,14-triol, 17-(cyclobutylmethyl)-4,5-epoxy-, (5alpha,6alpha)-
• (6alpha)-17-(cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol
• UNII-L2T84IQI2K
• Nalbuphinum
• 17-(Cyclobutylmethyl)-4,5alpha-epoxymorphinan-3,6alpha,14-triol
• Nalbuphinum [INN-Latin]

Nalbuphine (1.0mg/ml in Acetonitrile)

CAS: 20594-83-6

• Formula: C₂₁H₂₇NO₄
• Color and Shape: Colourless
• Molecular weight: 357.44

Nalbuphine

CAS: 20594-83-6

Nalbuphine is a potent opioid analgesic that binds to the mu-opioid receptor, but has a …

• Formula: C₂₁H₂₇NO₄
• Purity: Min. 95%
• Molecular weight: 357.40 g/mol