Hypercalcemia of Malignancy Factor (1-37) is a peptide that plays a significant role in the pathophysiology of hypercalcemia associated with malignancies. This factor is derived from parathyroid hormone-related peptide (PTHrP), which is often produced by certain tumors, leading to increased calcium levels in the blood. The peptide consists of 37 amino acids and exhibits structural similarities to parathyroid hormone, influencing calcium metabolism and bone resorption. Its primary function is to mimic the action of parathyroid hormone, stimulating osteoclast activity and promoting the release of calcium from bones into the bloodstream. This can result in various clinical manifestations, including weakness, confusion, and renal complications. The presence of Hypercalcemia of Malignancy Factor is particularly noted in certain cancers, such as squamous cell carcinoma of the lung and breast cancer. Understanding this factor is crucial for developing therapeutic strategies to manage hypercalcemia in cancer patients, as it highlights the interplay between tumor biology and calcium homeostasis.

Hypercalcemia Of Malignancy Factor (1-37) (Human, Rat)

206010-80-2: Hypercalcemia of Malignancy Factor (1-37) is a peptide that plays a significant role in the pathophysiology of hypercalcemia associated with malignancies. This factor is derived from parathyroid hormone-related peptide (PTHrP), which is often produced by certain tumors, leading to increased calcium levels in the blood. The peptide consists of 37 amino acids and exhibits structural similarities to parathyroid hormone, influencing calcium metabolism and bone resorption. Its primary function is to mimic the action of parathyroid hormone, stimulating osteoclast activity and promoting the release of calcium from bones into the bloodstream. This can result in various clinical manifestations, including weakness, confusion, and renal complications. The presence of Hypercalcemia of Malignancy Factor is particularly noted in certain cancers, such as squamous cell carcinoma of the lung and breast cancer. Understanding this factor is crucial for developing therapeutic strategies to manage hypercalcemia in cancer patients, as it highlights the interplay between tumor biology and calcium homeostasis.

pTHrP (1-37) is a parathyroid hormone-related protein sequence implicated in malignant hypercalcemia.

pTH-Related Protein (1-37) (human, mouse, rat)

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CAS 206010-80-2

Hypercalcemia Of Malignancy Factor (1-37) (Human, Rat)

pTH-Related Protein (1-37) (human, mouse, rat)

Ref: 01-4037178

pTH-Related Protein (1-37) (human, mouse, rat) trifluoroacetate salt

Ref: 3D-FP109511