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CAS 2061897-68-3

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(Tert-Butoxy)Carbonyl L-His(Trt)-Aib-OH

Description:
(Tert-Butoxy)Carbonyl L-His(Trt)-Aib-OH, commonly referred to as a protected amino acid derivative, is characterized by its complex structure that includes a tert-butoxycarbonyl (Boc) protecting group, a histidine residue with a triphenylmethyl (Trt) protecting group, and an α-aminoisobutyric acid (Aib) moiety. The Boc group serves to protect the amino group during peptide synthesis, while the Trt group protects the side chain of histidine, allowing for selective reactions without interfering with the amino acid's functional groups. This compound is typically used in peptide synthesis, particularly in the formation of peptides that require specific protection strategies to ensure the integrity of reactive sites. Its stability under various conditions, along with the ability to selectively deprotect the functional groups, makes it a valuable intermediate in the synthesis of bioactive peptides and pharmaceuticals. The presence of the Aib residue contributes to the overall rigidity and conformational stability of the resulting peptide, which can be crucial for biological activity.
Synonyms:
  • (S)-2-(2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid
  • 2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanamido]-2-methylpropanoic acid
  • Boc-His(Trt)-Aib-OH
  • Boc-L-His(trt)-Aib-OH
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