CAS 20633-67-4

calycosin-7-o-beta-d-glucoside

Description:

Calycosin-7-O-beta-D-glucoside is a naturally occurring flavonoid glycoside, primarily derived from the roots of the Astragalus species, particularly Astragalus membranaceus. This compound is characterized by its structure, which consists of a calycosin moiety linked to a glucose molecule via a beta-glycosidic bond. It exhibits various biological activities, including antioxidant, anti-inflammatory, and potential anticancer properties, making it of interest in pharmacological research. The compound is soluble in polar solvents, and its stability can be influenced by factors such as pH and temperature. Calycosin-7-O-beta-D-glucoside is often studied for its potential health benefits and therapeutic applications, particularly in traditional medicine. Its presence in herbal formulations highlights its significance in natural product chemistry and the exploration of plant-derived compounds for health and wellness. As with many flavonoids, it may also contribute to the color and flavor profiles of the plants from which it is extracted.

Formula: C₂₂H₂₂O₁₀

InChI: InChI=1/C22H22O10/c1-29-15-5-2-10(6-14(15)24)13-9-30-16-7-11(3-4-12(16)18(13)25)31-22-21(28)20(27)19(26)17(8-23)32-22/h2-7,9,17,19-24,26-28H,8H2,1H3/t17-,19-,20+,21-,22-/m1/s1

Synonyms:

• 3-(3-Hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen-7-yl beta-D-glucopyranoside
• 4H-1-benzopyran-4-one, 7-(beta-D-glucopyranosyloxy)-3-(3-hydroxy-4-methoxyphenyl)-
• Calycosin-O-Glucopyranoside
• Calycosin 7-O-Glucoside
• Calycosin 7-O-β-D-glucopyranoside

Calycosin 7-O-β-D-Glucopyranoside (3-(3-Hydroxy-4-methoxyphenyl)-4-oxo-4H-chromen7-yl β-D-glucopyranoside)

CAS: 20633-67-4

Other glycosides, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives

Formula: C₂₂H₂₂O₁₀

Color and Shape: Powder

Molecular weight: 446.1213

Ref: 45-1087483

4H-1-Benzopyran-4-one, 7-(β-D-glucopyranosyloxy)-3-(3-hydroxy-4-methoxyphenyl)-

CAS: 20633-67-4

Formula: C₂₂H₂₂O₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 446.4041

Ref: IN-DA002IGF

Calycosin-7-O-β-D-glucoside

CAS: 20633-67-4

Calycosin-7-O-β-D-glucoside

Purity: ≥98%

Molecular weight: 446.4g/mol

Ref: 54-BUP07155

calycosin-7-O-β-D-glucoside

CAS: 20633-67-4

Formula: C₂₂H₂₂O₁₀

Molecular weight: 446.41

Ref: 7W-GY4388

calycosin-7-O-β-D-glucoside

CAS: 20633-67-4

Calycosin-7-O-β-d-glucoside(CG) treatment can significantly reduce infarct volume, histological damage and BBB permeability in the in vivo MCAO ischemia–reperfusion rat model; inhibit the expression and activities of MMPs, and secure the expression of cav-1 and tight junction proteins in the microvessels isolated from ischemic rat cortex; scavenge NO, inhibit the activities of MMP-2 and MMP-9, and attenuate cell death in the in vitro cultured brain microvascular endothelial cells under OGD condition; thus CG could protect BBB integrity in experimental cerebral ischemia–reperfusion injury via regulating NO/cav-1/MMPs pathway.

Formula: C₂₂H₂₂O₁₀

Purity: 95%~99%

Color and Shape: Powder

Molecular weight: 446.408

Ref: BP-BP0306

Calycosin 7-glucoside

CAS: 20633-67-4

Natural glycoside

Formula: C₂₂H₂₂O₁₀

Purity: ≥ 95.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 446.41

Ref: 5G-82492

Calycosin-7-O-β-D-glucoside

CAS: 20633-67-4

Calycosin-7-O-β-D-glucoside is a flavonoid glycoside, which is primarily derived from the root of Astragalus membranaceus, a plant widely used in traditional Chinese medicine. This compound is characterized by its antioxidative and anti-inflammatory activities, mediated through modulation of various signaling pathways in the body, such as the MAPK and NF-κB pathways. It plays a significant role in scavenging free radicals and inhibiting inflammatory mediators, thus contributing to cellular protection and reducing oxidative stress.

Formula: C₂₂H₂₂O₁₀

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 446.4 g/mol

Ref: 3D-MC44349

Calycosin-7-O-β-D-glucoside

CAS: 20633-67-4

Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity.

Formula: C₂₂H₂₂O₁₀

Purity: 98% - 99.981%

Color and Shape: Solid

Molecular weight: 446.4

Ref: TM-T3388

Calycosin 7-O-β-D-glucoside

Controlled Product

CAS: 20633-67-4

Applications Calycosin 7-O-β-D-glucoside is one of seven constituent in Guanjiekang (GJK) that is formed by five medicinal herbs that is used for the rheumatoid arthritis (RA).
References Wu, J., et al.: Mol., 21, 1732/1-1732/12 (2016)

Formula: C₂₂H₂₂O₁₀

Color and Shape: Neat

Molecular weight: 446.40

Ref: TR-C148935