CAS 206361-99-1

Darunavir

Description:

Darunavir is an antiretroviral medication primarily used in the treatment of HIV/AIDS. It belongs to the class of drugs known as protease inhibitors, which work by inhibiting the protease enzyme, crucial for the viral replication process. Darunavir is characterized by its high potency against HIV strains, including those resistant to other protease inhibitors. The chemical formula of darunavir is C27H37N3O4S, and it features a sulfonamide group, which contributes to its antiviral activity. The substance is typically administered in combination with other antiretroviral agents to enhance efficacy and reduce the risk of resistance. Darunavir is known for its favorable pharmacokinetic profile, allowing for once-daily dosing in many cases. It is generally well-tolerated, although it may cause side effects such as gastrointestinal disturbances and potential liver enzyme elevations. As with all antiretroviral therapies, monitoring for drug interactions and adherence to treatment regimens is essential for optimal outcomes in HIV management.

Formula: C₂₇H₃₇N₃O₇S

InChI: InChI=1S/C27H37N3O7S/c1-18(2)15-30(38(33,34)21-10-8-20(28)9-11-21)16-24(31)23(14-19-6-4-3-5-7-19)29-27(32)37-25-17-36-26-22(25)12-13-35-26/h3-11,18,22-26,31H,12-17,28H2,1-2H3,(H,29,32)/t22-,23-,24+,25-,26+/m0/s1

InChI key: InChIKey=CJBJHOAVZSMMDJ-HEXNFIEUSA-N

SMILES: O(C(N[C@H]([C@@H](CN(S(=O)(=O)C1=CC=C(N)C=C1)CC(C)C)O)CC2=CC=CC=C2)=O)[C@@H]3[C@]4([C@@](OC3)(OCC4)[H])[H]

Synonyms:

• (3R,3aS,6aR)-Hexahydrofuro[2,3-b]furan-3-yl N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamate
• (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(2S,3R)-4-{[(4-aminophenyl)sulfonyl](2-methylpropyl)amino}-3-hydroxy-1-phenylbutan-2-yl]carbamate
• Carbamic acid, N-[(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
• Carbamic acid, [(1S,2R)-3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl ester
• Carbamic acid, [3-[[(4-aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-, hexahydrofuro[2,3-b]furan-3-yl ester, [3R-[3α(1S*,2R*),3aβ,6aβ]]-
• Darunavir & its intermediates
• Darunavir & its intermediates (R&D)
• Prezista
• TMC 114 (inhibitor)
• Tmc 114
• Tmc 41629
• Uic 94017

Darunavir

CAS: 206361-99-1

Formula: C₂₇H₃₇N₃O₇S

Color and Shape: White To Off-White Solid

Molecular weight: 547.67

Ref: 4Z-D-371

Darunavir

CAS: 206361-99-1

Darunavir

Purity: ≥98%

Molecular weight: 547.66g/mol

Ref: 54-BUP13325

Darunavir

CAS: 206361-99-1

Formula: C₂₇H₃₇N₃O₇S

Purity: ≥ 98.0%

Color and Shape: White to off-white powder or solid

Molecular weight: 547.66

Ref: 7W-GP5767

Darunavir

CAS: 206361-99-1

Darunavir

Purity: 98%

Molecular weight: 547.66g/mol

Ref: 54-OR1027115

Darunavir

Controlled Product

CAS: 206361-99-1

Formula: C₂₇H₃₇N₃O₇S

Color and Shape: Neat

Molecular weight: 547.66

Ref: 04-C11965000

Darunavir

CAS: 206361-99-1

Darunavir (TMC114) is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS.

Formula: C₂₇H₃₇N₃O₇S

Purity: 99.67% - 99.76%

Color and Shape: White Amorphous Solid

Molecular weight: 547.66

Ref: TM-T2324

Darunavir

CAS: 206361-99-1

Applications Second generation HIV-1-protease inhibitor; structurally similar to amprenavir. Antiviral. It is a COVID19-related research product.
References Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),

Formula: C₂₇H₃₇N₃O₇S

Color and Shape: Beige

Molecular weight: 547.66

Ref: TR-D193500

Darunavir

CAS: 206361-99-1

Darunavir is a HIV-1 protease inhibitor used orally in the treatment of patients with multi-drug resistant HIV-1 infection (Ghosh, 2007). It has also been shown to be effective against other infectious diseases such as hepatitis C virus and SARS coronavirus. Metabolized by cytochrome P450 3A (CYP3A) isoenzymes, darunavir is often administered together with ritonavir that prolongs its bioavaiability, giving a terminal elimination half-life (t1/2) of 15 hours (Back, 2008). The effect of darunavir on natural compounds such as matrix proteins and toll-like receptor activity has also been studied via high performance liquid chromatography (HPLC) experiments.

Formula: C₂₇H₃₇N₃O₇S

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 547.66 g/mol

Ref: 3D-FH20801

Darunavir

CAS: 206361-99-1

Formula: C₂₇H₃₇N₃O₇S

Purity: 98%

Color and Shape: Liquid, No data available.

Molecular weight: 547.67

Ref: 10-F547231