CAS 206645-99-0

Compstatin

Description:

Compstatin is a cyclic peptide that functions as a potent inhibitor of the complement system, specifically targeting the complement component C3. Its primary role is to prevent the activation of the complement pathway, which is crucial in various inflammatory and immune responses. Compstatin is characterized by its ability to bind to C3 with high affinity, thereby blocking its cleavage and subsequent activation. This property makes it a valuable compound in research related to autoimmune diseases, transplant rejection, and other conditions where complement activation plays a significant role. The substance is typically synthesized through solid-phase peptide synthesis and exhibits stability under physiological conditions. Compstatin's therapeutic potential is being explored in various clinical settings, particularly in conditions where excessive complement activation contributes to tissue damage. Its unique structure and mechanism of action make it a subject of interest in the development of complement-targeted therapies.

Formula: C₆₆H₉₉N₂₃O₁₇S₂

Synonyms:

• H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2, (Disulfide bond)
• L-Threoninamide, L-isoleucyl-L-cysteinyl-L-valyl-L-valyl-L-glutaminyl-L-α-aspartyl-L-tryptophylglycyl-L-histidyl-L-histidyl-L-arginyl-L-cysteinyl-, cyclic (2→12)-disulfide
• Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt (Disulfide bond)
• Compstatin,ICVVQDWGHHRCT, >98%
• H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2
• Compstatin

Compstatin

CAS: 206645-99-0

Formula: C₆₆H₉₉N₂₃O₁₇S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 1550.7662

Ref: IN-DA00C1FH

Compstatin

CAS: 206645-99-0

Compstatin, a cyclic tridecapeptide, which was originally discovered from phage-display libraries, is a highly potent and selective C3 inhibitor.

Formula: C₆₆H₉₉N₂₃O₁₇S₂

Purity: >99.99%

Color and Shape: Solid

Molecular weight: 1550.77

Ref: TM-TP1304

Compstatin trifluoroacetate salt

CAS: 206645-99-0

Compstatin trifluoroacetate salt H-Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 trifluoroacetate salt is a cyclic peptide with antiangiogenic and anticancer properties. Compstatin is an analog of a human serum albumin protein, which has been shown to have significant cytotoxicity in vivo. The analog has been shown to bind to the endothelial cell receptor, inhibiting angiogenesis. This drug also inhibits cancer cell proliferation by interfering with the synthesis of DNA and RNA. Compstatin trifluoroacetate salt H-Ile-Cys-Val -Val -Gln -Asp -Trp -Gly -His -His -Arg -Cys -Thr NH2 trifluoroacetate salt (disulfide bond) can be synthesized in

Formula: C₆₆H₉₉N₂₃O₁₇S₂

Purity: Min. 95%

Molecular weight: 1,550.77 g/mol

Ref: 3D-FC109863

Compstatin

CAS: 206645-99-0

Compstatin, ICVVQDWGHHRCT, is a 13-residue cyclic peptide that inhibits complement activation by binding to complement component C3.

Formula: C₆₆H₉₉N₂₃O₁₇S₂

Purity: > 97%

Color and Shape: White

Molecular weight: 1550.79

Ref: 01-4045832