CAS 206646-04-0

[(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phosphonooxy-phosphinic acid

Description:

The chemical substance known as [(1R)-2-(6-aminopurin-9-yl)-1-methyl-ethoxy]methyl-phosphonooxy-phosphinic acid, with the CAS number 206646-04-0, is a phosphonic acid derivative that exhibits significant biological activity, particularly in the context of antiviral properties. This compound features a purine base structure, which is characteristic of nucleobases, and is modified with a phosphonic acid moiety that enhances its stability and bioactivity. The presence of the amino group contributes to its potential interactions with biological targets, making it relevant in medicinal chemistry. Its unique structure allows it to mimic natural nucleotides, which can interfere with nucleic acid synthesis in pathogens. The compound is typically studied for its potential applications in antiviral therapies, particularly against viruses that rely on nucleic acid replication. Additionally, its physicochemical properties, such as solubility and stability, are crucial for its efficacy in biological systems. Overall, this substance represents a significant area of research in the development of antiviral agents.

Formula: C₉H₁₅N₅O₇P₂

InChI: InChI=1/C9H15N5O7P2/c1-6(20-5-22(15,16)21-23(17,18)19)2-14-4-13-7-8(10)11-3-12-9(7)14/h3-4,6H,2,5H2,1H3,(H,15,16)(H2,10,11,12)(H2,17,18,19)/t6-/m1/s1

SMILES: C[C@H](Cn1cnc2c(N)ncnc12)OCP(=O)(O)OP(=O)(O)O

Isohypophosphoric acid, P'-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]-

CAS: 206646-04-0

Formula: C₉H₁₅N₅O₇P₂

Molecular weight: 367.1922

Ref: IN-DA002IKY

Tenofovir monophosphate

CAS: 206646-04-0

Formula: C₉H₁₅N₅O₇P₂

Molecular weight: 367.20

Ref: 4Z-T-024

Tenofovir Phosphate Diammonia Salt, >90%

Controlled Product

CAS: 206646-04-0

Applications Tenofovir Phosphate Diammonia Salt is a metabolite of Tenofovir (T018500), an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
References Michelson, A.M., et al.: Biochim. Biophys. Acta, 91, 1 (1964); Rosenberg, I., et al.: Collect. Czeck. Chem. Commun., 50, 1507 (1985); Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997); Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005),; Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006); Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007)

Formula: C₉H₂₁N₇O₇P₂

Purity: >90%

Color and Shape: Neat

Molecular weight: 401.25

Ref: TR-T018560

Tenofovir Phosphate Diammonia Salt-13C5

Controlled Product

CAS: 206646-04-0

Formula: C₄C₅H₁₅N₅O₇P₂•2(NH₃)

Color and Shape: Neat

Molecular weight: 384.07122

Ref: TR-T018562

Tenofovir monophosphate

CAS: 206646-04-0

Formula: C₉H₁₅N₅O₇P₂

Molecular weight: 367.2

Ref: ST-EA-CP-T5085